Developmental and Comparative Immunology

, volume 92 , pages 60-68

The role of αβ T-cells in spontaneous regression of melanoma tumors in swine

Zuzana Sinkorova ¹

Monika Červinková ^{2, 3}

Jiří Šinkora ⁴

Katerina Stepanova ⁵

Marek Šinkora ⁶

Hide authors affiliations Show authors affiliations: 6 affiliations

Department of Radiobiology, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic. Electronic address: zuzana.sinkorova@unob.cz. |

Laboratory of Tumor Biology, Institute of Animal Physiology and Genetics, Czech Academy of Sciences, Libechov, Czech Republic |

Surgical Department, 1st Medical Faculty of Charles University and Hospital Na Bulovce, Prague, Czech Republic. |

⁴

Life Sciences, Becton Dickinson Czechia, s.r.o., Prague, Czech Republic. |

⁵

Laboratory of Gnotobiology, Institute of Microbiology of the Czech Academy of Sciences, Novy Hradek, Czech Republic |

⁶

Laboratory of Gnotobiology, Institute of Microbiology of the Czech Academy of Sciences, Novy Hradek, Czech Republic. Electronic address: marek@biomed.cas.cz. |

Publication type: Journal Article

Publication date: 2019-03-01

Elsevier

Developmental and Comparative Immunology

scimago Q2

wos Q1

SJR: 0.631

CiteScore: 6.2

Impact factor: 2.4

ISSN: 0145305X, 18790089

DOI: 10.1016/j.dci.2018.10.001

Copy DOI

PubMed ID: 30308209

Developmental Biology

Immunology

Abstract

Using a porcine model, we describe Melanoma-Associated CD4+CD8hi T-lymphocytes (MATL) in peripheral blood that increase during melanoma regression. These MATL possess the CD4+CD8hi phenotype and they have their direct counterparts in Tumor Infiltrating Lymphocytes (TIL) isolated from melanoma loci. Both MATL and CD4+CD8hi TIL have a similar expression of selected markers indicating that they represent effector/memory αβ T-cell subset. Moreover, although TIL also contain CD4-CD8+ T-cells, only CD4+CD8hi TIL expand during melanoma regression. Importantly, TIL isolated from different pigs and different melanoma loci among the same pig have similar composition of CD4/CD8 subsets, indicating that the composition of the MATL and TIL compartment is identical. Analysis of sorted cells from regressing pigs revealed a unique MATL subpopulation with mono-specific T-cell receptor that was further analyzed by sequencing. These results indicate that pigs regressing melanomas possess a characteristic population of recirculating T-cells playing a role in tumor control and regression.

Found

1 citation

Razumov Ivan

51 publications, 358 citations

h-index: 12

Novosibirsk State University

Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences

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GOST Copy

Cizkova J. et al. The role of αβ T-cells in spontaneous regression of melanoma tumors in swine // Developmental and Comparative Immunology. 2019. Vol. 92. pp. 60-68.

GOST all authors (up to 50) Copy

Sinkorova Z., Červinková M., Šinkora J., Stepanova K., Šinkora M. The role of αβ T-cells in spontaneous regression of melanoma tumors in swine // Developmental and Comparative Immunology. 2019. Vol. 92. pp. 60-68.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1016/j.dci.2018.10.001

UR - https://doi.org/10.1016/j.dci.2018.10.001

TI - The role of αβ T-cells in spontaneous regression of melanoma tumors in swine

T2 - Developmental and Comparative Immunology

AU - Sinkorova, Zuzana

AU - Červinková, Monika

AU - Šinkora, Jiří

AU - Stepanova, Katerina

AU - Šinkora, Marek

PY - 2019

DA - 2019/03/01

PB - Elsevier

SP - 60-68

VL - 92

PMID - 30308209

SN - 0145-305X

SN - 1879-0089

ER -

BibTex

Cite this

BibTex (up to 50 authors) Copy

@article{2019_Cizkova,

author = {Zuzana Sinkorova and Monika Červinková and Jiří Šinkora and Katerina Stepanova and Marek Šinkora},

title = {The role of αβ T-cells in spontaneous regression of melanoma tumors in swine},

journal = {Developmental and Comparative Immunology},

year = {2019},

volume = {92},

publisher = {Elsevier},

month = {mar},

url = {https://doi.org/10.1016/j.dci.2018.10.001},

pages = {60--68},

doi = {10.1016/j.dci.2018.10.001}

}

Publisher

Elsevier

Journal

Developmental and Comparative Immunology

scimago Q2

wos Q1

SJR

0.631

CiteScore

6.2

Impact factor

2.4

ISSN

0145305X (Print)

18790089 (Electronic)