Elsevier
Drug and Alcohol Dependence
,  volume 271 ,  pages 112632

Buprenorphine-Naloxone versus Buprenorphine for Opioid Use Disorder During Pregnancy: A Systematic Review and Meta-Analysis

Fernanda Ribeiro de Lima 1
, 
Gabriela Oliveira Gonçalves Molino 2
, 
Mariano Gallo Ruelas 3
, 
Eduardo Cerchi Barbosa 4
, 
Pedro Henrique Costa Matos da Silva 5
, 
Felipe Bandeira de Melo Guimarães 6
, 
Arthur Bezerra Cavalcanti Petrucci 7
, 
Giovanna Hanike Santos da Silva 8
, 
Ângelo Eduardo Espíndola Sbardelotto 9
, 
Saulo Bernardo Lança 10
, 
Alicja Garbacka 11
1
 
2
 
Department of Medicine, Federal University of Health Sciences of Porto Alegre, Porto Alegre, Brazil | 
3
 
Instituto de Investigación Nutricional, Lima, Peru | 
4
 
Department of Medicine, Evangelical University of Goiás, Anápolis, Brazil | 
5
 
6
 
7
 
8
 
Department of Medicine, Catholic University of Pernambuco, Recife, Brazil | 
9
 
10
 
11
 
Institute of Psychiatry and Neurology, Child and Adolescent Psychiatry Clinic, Warsaw, Poland | 
Publication type: Journal Article
Publication date: 2025-06-01
Elsevier
scimago Q1
wos Q1
SJR: 1.657
CiteScore: 7.9
Impact factor: 3.6
ISSN: 03768716, 18790046
Abstract
BackgroundThe standard of care for treating opioid use disorder (OUD) during pregnancy includes either buprenorphine or methadone. Although buprenorphine-naloxone presents an alternative due to the reduced risk of misuse , evidence regarding its impact on pregnancy and infant health remains limited. This systematic review and meta-analysis aims to compare buprenorphine-naloxone vs buprenorphine alone for OUD during pregnancy, assessing gestational and neonatal outcomes.
Found 
Found 

Top-30

Journals

1
Obstetrics and Gynecology
Obstetrics and Gynecology, 1, 50%
Obstetrics and Gynecology
1 publication, 50%
Addiction
Addiction, 1, 50%
Addiction
1 publication, 50%
1

Publishers

1
Ovid Technologies (Wolters Kluwer Health)
Ovid Technologies (Wolters Kluwer Health), 1, 50%
Ovid Technologies (Wolters Kluwer Health)
1 publication, 50%
Wiley
Wiley, 1, 50%
Wiley
1 publication, 50%
1
  • We do not take into account publications without a DOI.
  • Statistics recalculated weekly.

Are you a researcher?

Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
2
Share
Cite this
GOST |
Cite this
GOST Copy
de Lima F. R. et al. Buprenorphine-Naloxone versus Buprenorphine for Opioid Use Disorder During Pregnancy: A Systematic Review and Meta-Analysis // Drug and Alcohol Dependence. 2025. Vol. 271. p. 112632.
GOST all authors (up to 50) Copy
de Lima F. R., Molino G. O. G., Gallo Ruelas M., Barbosa E. C., Silva P. H. C. M. D., Guimarães F. B. D. M., Petrucci A. B. C., Silva G. H. S. D., Sbardelotto Â. E. E., Lança S. B., Garbacka A. Buprenorphine-Naloxone versus Buprenorphine for Opioid Use Disorder During Pregnancy: A Systematic Review and Meta-Analysis // Drug and Alcohol Dependence. 2025. Vol. 271. p. 112632.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1016/j.drugalcdep.2025.112632
UR - https://linkinghub.elsevier.com/retrieve/pii/S0376871625000857
TI - Buprenorphine-Naloxone versus Buprenorphine for Opioid Use Disorder During Pregnancy: A Systematic Review and Meta-Analysis
T2 - Drug and Alcohol Dependence
AU - de Lima, Fernanda Ribeiro
AU - Molino, Gabriela Oliveira Gonçalves
AU - Gallo Ruelas, Mariano
AU - Barbosa, Eduardo Cerchi
AU - Silva, Pedro Henrique Costa Matos da
AU - Guimarães, Felipe Bandeira de Melo
AU - Petrucci, Arthur Bezerra Cavalcanti
AU - Silva, Giovanna Hanike Santos da
AU - Sbardelotto, Ângelo Eduardo Espíndola
AU - Lança, Saulo Bernardo
AU - Garbacka, Alicja
PY - 2025
DA - 2025/06/01
PB - Elsevier
SP - 112632
VL - 271
SN - 0376-8716
SN - 1879-0046
ER -
BibTex
Cite this
BibTex (up to 50 authors) Copy
@article{2025_de Lima,
author = {Fernanda Ribeiro de Lima and Gabriela Oliveira Gonçalves Molino and Mariano Gallo Ruelas and Eduardo Cerchi Barbosa and Pedro Henrique Costa Matos da Silva and Felipe Bandeira de Melo Guimarães and Arthur Bezerra Cavalcanti Petrucci and Giovanna Hanike Santos da Silva and Ângelo Eduardo Espíndola Sbardelotto and Saulo Bernardo Lança and Alicja Garbacka},
title = {Buprenorphine-Naloxone versus Buprenorphine for Opioid Use Disorder During Pregnancy: A Systematic Review and Meta-Analysis},
journal = {Drug and Alcohol Dependence},
year = {2025},
volume = {271},
publisher = {Elsevier},
month = {jun},
url = {https://linkinghub.elsevier.com/retrieve/pii/S0376871625000857},
pages = {112632},
doi = {10.1016/j.drugalcdep.2025.112632}
}