The total synthesis of fukiic acid, an HIV-1 integrase inhibitor
Clémence Queffélec
1
,
Fabrice Bailly
1
,
Gladys Mbemba
2
,
Jean-François Mouscadet
2
,
Zeger Debyser
3
,
Myriam Witvrouw
3
,
Philippe Cotelle
1
2
Laboratoire de Biotechnologies et Pharmacologie Génétique Appliquée, CNRS UMR 8113, Ecole Normale Supérieure de Cachan, 61 av du Président Wilson, 94235 Cachan, France
|
Publication type: Journal Article
Publication date: 2008-10-01
scimago Q1
wos Q1
SJR: 1.142
CiteScore: 11.3
Impact factor: 5.9
ISSN: 02235234, 17683254
PubMed ID:
18243421
Organic Chemistry
Drug Discovery
General Medicine
Pharmacology
Abstract
A successful synthesis of fukiic acid is described in 7% overall yield (6 steps from veratraldehyde). rac-Fukiic acid was found to be a potent inhibitor of HIV-1 integrase but did not reveal any antiviral activity in the MT-4 cells assay.
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Total citations:
8
Citations from 2024:
1
(12.5%)
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MLA
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GOST
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Queffélec C. et al. The total synthesis of fukiic acid, an HIV-1 integrase inhibitor // European Journal of Medicinal Chemistry. 2008. Vol. 43. No. 10. pp. 2268-2271.
GOST all authors (up to 50)
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Queffélec C., Bailly F., Mbemba G., Mouscadet J., Debyser Z., Witvrouw M., Cotelle P. The total synthesis of fukiic acid, an HIV-1 integrase inhibitor // European Journal of Medicinal Chemistry. 2008. Vol. 43. No. 10. pp. 2268-2271.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.ejmech.2007.12.013
UR - https://doi.org/10.1016/j.ejmech.2007.12.013
TI - The total synthesis of fukiic acid, an HIV-1 integrase inhibitor
T2 - European Journal of Medicinal Chemistry
AU - Queffélec, Clémence
AU - Bailly, Fabrice
AU - Mbemba, Gladys
AU - Mouscadet, Jean-François
AU - Debyser, Zeger
AU - Witvrouw, Myriam
AU - Cotelle, Philippe
PY - 2008
DA - 2008/10/01
PB - Elsevier
SP - 2268-2271
IS - 10
VL - 43
PMID - 18243421
SN - 0223-5234
SN - 1768-3254
ER -
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BibTex (up to 50 authors)
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@article{2008_Queffélec,
author = {Clémence Queffélec and Fabrice Bailly and Gladys Mbemba and Jean-François Mouscadet and Zeger Debyser and Myriam Witvrouw and Philippe Cotelle},
title = {The total synthesis of fukiic acid, an HIV-1 integrase inhibitor},
journal = {European Journal of Medicinal Chemistry},
year = {2008},
volume = {43},
publisher = {Elsevier},
month = {oct},
url = {https://doi.org/10.1016/j.ejmech.2007.12.013},
number = {10},
pages = {2268--2271},
doi = {10.1016/j.ejmech.2007.12.013}
}
Cite this
MLA
Copy
Queffélec, Clémence, et al. “The total synthesis of fukiic acid, an HIV-1 integrase inhibitor.” European Journal of Medicinal Chemistry, vol. 43, no. 10, Oct. 2008, pp. 2268-2271. https://doi.org/10.1016/j.ejmech.2007.12.013.