Synthesis of novel sulfanilamide-derived 1,2,3-triazoles and their evaluation for antibacterial and antifungal activities
Publication type: Journal Article
Publication date: 2010-10-01
scimago Q1
wos Q1
SJR: 1.142
CiteScore: 11.3
Impact factor: 5.9
ISSN: 02235234, 17683254
PubMed ID:
20708826
Organic Chemistry
Drug Discovery
General Medicine
Pharmacology
Abstract
A series of novel sulfanilamide-derived 1,2,3-triazole compounds were synthesized in excellent yields via 1,3-dipolar cycloaddition and confirmed by MS, IR and NMR spectra as well as elemental analyses. All the compounds were screened in vitro for their antibacterial and antifungal activities. Preliminary results indicated that some target compounds exhibited promising antibacterial potency. Especially, 4-amino-N-((1-dodecyl-1H-1,2,3-triazol-4-yl)methyl) benzenesulfonamide, N-((1-(2,4-dichlorobenzyl)- 1H-1,2,3-triazol-4-yl)methyl)-4-aminobenzenesulfonamide and 4-amino-N-((1-(2,4-difluorobenzyl)- 1H-1,2,3-triazol-4-yl)methyl) benzenesulfonamide were found to be the most potent compounds against all the tested strains except for Candida albicans (ATCC76615) and Candida mycoderma.
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Total citations:
326
Citations from 2024:
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(10.74%)
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GOST
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Wang X., Wan K., Zhou C. Synthesis of novel sulfanilamide-derived 1,2,3-triazoles and their evaluation for antibacterial and antifungal activities // European Journal of Medicinal Chemistry. 2010. Vol. 45. No. 10. pp. 4631-4639.
GOST all authors (up to 50)
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Wang X., Wan K., Zhou C. Synthesis of novel sulfanilamide-derived 1,2,3-triazoles and their evaluation for antibacterial and antifungal activities // European Journal of Medicinal Chemistry. 2010. Vol. 45. No. 10. pp. 4631-4639.
Cite this
RIS
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TY - JOUR
DO - 10.1016/j.ejmech.2010.07.031
UR - https://doi.org/10.1016/j.ejmech.2010.07.031
TI - Synthesis of novel sulfanilamide-derived 1,2,3-triazoles and their evaluation for antibacterial and antifungal activities
T2 - European Journal of Medicinal Chemistry
AU - Wang, Xianlong
AU - Wan, Kun
AU - Zhou, Chenghe
PY - 2010
DA - 2010/10/01
PB - Elsevier
SP - 4631-4639
IS - 10
VL - 45
PMID - 20708826
SN - 0223-5234
SN - 1768-3254
ER -
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BibTex (up to 50 authors)
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@article{2010_Wang,
author = {Xianlong Wang and Kun Wan and Chenghe Zhou},
title = {Synthesis of novel sulfanilamide-derived 1,2,3-triazoles and their evaluation for antibacterial and antifungal activities},
journal = {European Journal of Medicinal Chemistry},
year = {2010},
volume = {45},
publisher = {Elsevier},
month = {oct},
url = {https://doi.org/10.1016/j.ejmech.2010.07.031},
number = {10},
pages = {4631--4639},
doi = {10.1016/j.ejmech.2010.07.031}
}
Cite this
MLA
Copy
Wang, Xianlong, et al. “Synthesis of novel sulfanilamide-derived 1,2,3-triazoles and their evaluation for antibacterial and antifungal activities.” European Journal of Medicinal Chemistry, vol. 45, no. 10, Oct. 2010, pp. 4631-4639. https://doi.org/10.1016/j.ejmech.2010.07.031.