Synthesis and biological evaluation of some 1,3,4-oxadiazole derivatives
K Manjunatha
1
,
Boja Boja Poojary
1
,
Prajwal L. Lobo
1
,
Jennifer Fernandes
2
,
N.Suchetha Kumari
3
2
Department of Pharmachemistry, N G S M College of Pharmacy, Panner, Deralakatte-574 160, Karnataka, India
|
3
Department of Biochemistry, K S Hegde Medical Academy, Deralakatte-574 162, Karnataka, India
|
Publication type: Journal Article
Publication date: 2010-11-01
scimago Q1
wos Q1
SJR: 1.142
CiteScore: 11.3
Impact factor: 5.9
ISSN: 02235234, 17683254
PubMed ID:
20828888
Organic Chemistry
Drug Discovery
General Medicine
Pharmacology
Abstract
The acid hydrazides (2) derived from ibuprofen and 4-methylthiophenyl acetic acids have been subjected to cyclization with carbon disulphide under basic conditions to yield 1,3,4-oxadiazol-2-thiones (3) which on aminomethylation with formaldehyde and secondary amines afforded a series of Mannich bases (4 and 5). Purity of the compounds has been confirmed by TLC. Structures of these compounds were established on the basis of elemental analyses and spectral studies. The newly synthesized compounds were evaluated for their anti-inflammatory, analgesic, ulcerogenic and antimicrobial activities.
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123
Total citations:
123
Citations from 2024:
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(10.57%)
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Manjunatha K. et al. Synthesis and biological evaluation of some 1,3,4-oxadiazole derivatives // European Journal of Medicinal Chemistry. 2010. Vol. 45. No. 11. pp. 5225-5233.
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Manjunatha K., Boja Poojary B., Lobo P. L., Fernandes J., Kumari N. Synthesis and biological evaluation of some 1,3,4-oxadiazole derivatives // European Journal of Medicinal Chemistry. 2010. Vol. 45. No. 11. pp. 5225-5233.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.ejmech.2010.08.039
UR - https://doi.org/10.1016/j.ejmech.2010.08.039
TI - Synthesis and biological evaluation of some 1,3,4-oxadiazole derivatives
T2 - European Journal of Medicinal Chemistry
AU - Manjunatha, K
AU - Boja Poojary, Boja
AU - Lobo, Prajwal L.
AU - Fernandes, Jennifer
AU - Kumari, N.Suchetha
PY - 2010
DA - 2010/11/01
PB - Elsevier
SP - 5225-5233
IS - 11
VL - 45
PMID - 20828888
SN - 0223-5234
SN - 1768-3254
ER -
Cite this
BibTex (up to 50 authors)
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@article{2010_Manjunatha,
author = {K Manjunatha and Boja Boja Poojary and Prajwal L. Lobo and Jennifer Fernandes and N.Suchetha Kumari},
title = {Synthesis and biological evaluation of some 1,3,4-oxadiazole derivatives},
journal = {European Journal of Medicinal Chemistry},
year = {2010},
volume = {45},
publisher = {Elsevier},
month = {nov},
url = {https://doi.org/10.1016/j.ejmech.2010.08.039},
number = {11},
pages = {5225--5233},
doi = {10.1016/j.ejmech.2010.08.039}
}
Cite this
MLA
Copy
Manjunatha, K., et al. “Synthesis and biological evaluation of some 1,3,4-oxadiazole derivatives.” European Journal of Medicinal Chemistry, vol. 45, no. 11, Nov. 2010, pp. 5225-5233. https://doi.org/10.1016/j.ejmech.2010.08.039.