Synthesis, characterization and preliminary anticonvulsant evaluation of some 4-alkyl-1,2,4-triazoles
Publication type: Journal Article
Publication date: 2013-03-01
scimago Q1
wos Q1
SJR: 1.142
CiteScore: 11.3
Impact factor: 5.9
ISSN: 02235234, 17683254
PubMed ID:
23291122
Organic Chemistry
Drug Discovery
General Medicine
Pharmacology
Abstract
Designed and synthesized 4-alkyl-1,2,4-triazole-3-thione derivatives showed significant anticonvulsant activity, determined in the maximal electroshock-induced seizure (MES) test. The chemical structure of all new compounds was confirmed by spectral methods ((1)H NMR, (13)C NMR, IR, MS). A sensitive and selective method was elaborated for the determination of the anticonvulsant compounds levels in mice brain tissue, based on HPLC with diode array detector (DAD). Chromatographic tests showed that lack of anticonvulsant effect of two derivatives (15, 16) with long alkyl chains at N-4 position of the 1,2,4-triazole ring was due to the inability to cross the blood-brain barrier (BBB).
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72
Total citations:
72
Citations from 2024:
4
(5.56%)
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GOST
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Plech T. et al. Synthesis, characterization and preliminary anticonvulsant evaluation of some 4-alkyl-1,2,4-triazoles // European Journal of Medicinal Chemistry. 2013. Vol. 60. pp. 208-215.
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Plech T., Luszczki J., Wujec M., Flieger J., Pizoń M. Synthesis, characterization and preliminary anticonvulsant evaluation of some 4-alkyl-1,2,4-triazoles // European Journal of Medicinal Chemistry. 2013. Vol. 60. pp. 208-215.
Cite this
RIS
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TY - JOUR
DO - 10.1016/j.ejmech.2012.11.026
UR - https://doi.org/10.1016/j.ejmech.2012.11.026
TI - Synthesis, characterization and preliminary anticonvulsant evaluation of some 4-alkyl-1,2,4-triazoles
T2 - European Journal of Medicinal Chemistry
AU - Plech, Tomasz
AU - Luszczki, J.
AU - Wujec, Monika
AU - Flieger, Jolanta
AU - Pizoń, M.
PY - 2013
DA - 2013/03/01
PB - Elsevier
SP - 208-215
VL - 60
PMID - 23291122
SN - 0223-5234
SN - 1768-3254
ER -
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BibTex (up to 50 authors)
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@article{2013_Plech,
author = {Tomasz Plech and J. Luszczki and Monika Wujec and Jolanta Flieger and M. Pizoń},
title = {Synthesis, characterization and preliminary anticonvulsant evaluation of some 4-alkyl-1,2,4-triazoles},
journal = {European Journal of Medicinal Chemistry},
year = {2013},
volume = {60},
publisher = {Elsevier},
month = {mar},
url = {https://doi.org/10.1016/j.ejmech.2012.11.026},
pages = {208--215},
doi = {10.1016/j.ejmech.2012.11.026}
}