Microwave-assisted synthesis of some new pyrazolopyridines and their antioxidant, antitumor and antimicrobial activities
Publication type: Journal Article
Publication date: 2013-08-01
scimago Q1
wos Q1
SJR: 1.142
CiteScore: 11.3
Impact factor: 5.9
ISSN: 02235234, 17683254
PubMed ID:
23831694
Organic Chemistry
Drug Discovery
General Medicine
Pharmacology
Abstract
The chemical behavior of 4-(dimethylaminomethylene)-1-phenyl-3-(pyridin-3-yl)-1H-pyrazol-5(4H)-one (enaminone) (2) toward some active methylene reagents has been reported to give pyrazolopyridine derivatives. All the reactions were carried out by conventional heating and microwave irradiation technique. The antioxidant activity of the prepared compounds was studied using 1,1-phenyl-2-picrylhydrazyl (DPPH) assay. Compounds (4c) and (4d) showed the highest activity. The antitumor activity against liver and breast cell lines was tested. Compounds (6), (9) and (11) showed the highest activity for liver cell line while compounds (6) and (9) showed the highest activity for breast cell line. Compounds (4a-d) were screened for their antibacterial activity against Gram-positive, Gram-negative bacteria and antifungal activity.
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67
Total citations:
67
Citations from 2024:
6
(9.09%)
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GOST
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El Borai M. A. et al. Microwave-assisted synthesis of some new pyrazolopyridines and their antioxidant, antitumor and antimicrobial activities // European Journal of Medicinal Chemistry. 2013. Vol. 66. pp. 415-422.
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El Borai M. A., Rizk H. F., Beltagy D. M., EL-DEEB I. M. Microwave-assisted synthesis of some new pyrazolopyridines and their antioxidant, antitumor and antimicrobial activities // European Journal of Medicinal Chemistry. 2013. Vol. 66. pp. 415-422.
Cite this
RIS
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TY - JOUR
DO - 10.1016/j.ejmech.2013.04.043
UR - https://doi.org/10.1016/j.ejmech.2013.04.043
TI - Microwave-assisted synthesis of some new pyrazolopyridines and their antioxidant, antitumor and antimicrobial activities
T2 - European Journal of Medicinal Chemistry
AU - El Borai, Mohamed A
AU - Rizk, Hala F
AU - Beltagy, Doha M
AU - EL-DEEB, IBRAHIM M.
PY - 2013
DA - 2013/08/01
PB - Elsevier
SP - 415-422
VL - 66
PMID - 23831694
SN - 0223-5234
SN - 1768-3254
ER -
Cite this
BibTex (up to 50 authors)
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@article{2013_El Borai,
author = {Mohamed A El Borai and Hala F Rizk and Doha M Beltagy and IBRAHIM M. EL-DEEB},
title = {Microwave-assisted synthesis of some new pyrazolopyridines and their antioxidant, antitumor and antimicrobial activities},
journal = {European Journal of Medicinal Chemistry},
year = {2013},
volume = {66},
publisher = {Elsevier},
month = {aug},
url = {https://doi.org/10.1016/j.ejmech.2013.04.043},
pages = {415--422},
doi = {10.1016/j.ejmech.2013.04.043}
}