Open Access
Prediction of the skin permeability of topical drugs using in silico and in vitro models
Cristina Alonso
1
,
Victor Carrer
1
,
Sonia Espinosa
2
,
Míriam Zanuy
2
,
Mònica Córdoba
2
,
Bernat Vidal
2
,
María Luz Domínguez
2
,
Nuria Godessart
2
,
Luisa Coderch
1
,
Mercè Pont
2
2
Almirall R&D Center, Ctra. Laureà Miró, 408-410, 08980 Sant Feliu de Llobregat, Barcelona, Spain.
|
Publication type: Journal Article
Publication date: 2019-08-01
scimago Q1
wos Q1
SJR: 0.827
CiteScore: 9.1
Impact factor: 4.7
ISSN: 09280987, 18790720
PubMed ID:
31163216
Pharmaceutical Science
Abstract
The main challenge of topically applied drugs is to overcome the skin barrier to reach the site of action at the concentration needed for efficacy. In the research of new topical drugs, design of molecules with optimized properties for skin penetration is a key factor and assays for its characterization are needed. A group of 20 representative topical molecules of clinical use were studied in two in silico models (Potts & Guy and Barratt), and an in vitro assay with artificial membrane (Skin-PAMPA). A subset of 9 drugs were also evaluated in the Franz cells assay, formulated in a solvent and in a marketed formulation. Each assay allowed us to grade compounds according to their permeability value. Globally good alignments were found for the studied compounds when comparing models, although discrepancies for some compounds such as tazarotene, tacrolimus, ketoconazole and metronidazole were observed. Overall, the studied in silico and the in vitro models are useful tools to support selection and characterization of research compounds in terms of skin permeability.
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Citations from 2024:
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GOST
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Alonso C. et al. Prediction of the skin permeability of topical drugs using in silico and in vitro models // European Journal of Pharmaceutical Sciences. 2019. Vol. 136. p. 104945.
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Alonso C., Carrer V., Espinosa S., Zanuy M., Córdoba M., Vidal B., Domínguez M. L., Godessart N., Coderch L., Pont M. Prediction of the skin permeability of topical drugs using in silico and in vitro models // European Journal of Pharmaceutical Sciences. 2019. Vol. 136. p. 104945.
Cite this
RIS
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TY - JOUR
DO - 10.1016/j.ejps.2019.05.023
UR - https://doi.org/10.1016/j.ejps.2019.05.023
TI - Prediction of the skin permeability of topical drugs using in silico and in vitro models
T2 - European Journal of Pharmaceutical Sciences
AU - Alonso, Cristina
AU - Carrer, Victor
AU - Espinosa, Sonia
AU - Zanuy, Míriam
AU - Córdoba, Mònica
AU - Vidal, Bernat
AU - Domínguez, María Luz
AU - Godessart, Nuria
AU - Coderch, Luisa
AU - Pont, Mercè
PY - 2019
DA - 2019/08/01
PB - Elsevier
SP - 104945
VL - 136
PMID - 31163216
SN - 0928-0987
SN - 1879-0720
ER -
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BibTex (up to 50 authors)
Copy
@article{2019_Alonso,
author = {Cristina Alonso and Victor Carrer and Sonia Espinosa and Míriam Zanuy and Mònica Córdoba and Bernat Vidal and María Luz Domínguez and Nuria Godessart and Luisa Coderch and Mercè Pont},
title = {Prediction of the skin permeability of topical drugs using in silico and in vitro models},
journal = {European Journal of Pharmaceutical Sciences},
year = {2019},
volume = {136},
publisher = {Elsevier},
month = {aug},
url = {https://doi.org/10.1016/j.ejps.2019.05.023},
pages = {104945},
doi = {10.1016/j.ejps.2019.05.023}
}