European Journal of Radiology, volume 180, pages 111694

[68 Ga]Ga-CXCR4 PET/CT imaging in high-grade glioma for assessment of CXCR4 receptor expression

Hessamoddin Roustaei ^{1, 2}

Habibeh Vosoughi ³

Emran Askari ²

Bagher Aziz Kalantari ⁴

Nasim Norouzbeigi ³

Kazem Anvari ⁵

Mohsen Beheshti ¹

Kamran Aryana ²

Hide authors affiliations

Division of Molecular Imaging & Theranostics, Department of Nuclear Medicine, University Hospital Salzburg, Paracelsus Medical University, 5020 Salzburg, Austria |

Nuclear Medicine research center, Mashhad University of Medical sciences, Mashhad, Iran |

Nuclear Medicine Department, Razavi Hospital, Imam Reza International University, Mashhad, Iran |

⁴

Karaj Branch, Azad University, Karaj, Iran |

⁵

Cancer Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran |

Publication type: Journal Article

Publication date: 2024-11-01

Elsevier

Journal: European Journal of Radiology

scimago Q1

SJR: 0.976

CiteScore: 6.7

Impact factor: 3.2

ISSN: 0720048X, 18727727

DOI: 10.1016/j.ejrad.2024.111694

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Abstract

Gliomas account for 75 % of primary malignant CNS tumors. High-grade glioma (CNS WHO grades 3 and 4) have an unfavorable treatment response and poor outcome. CXCR4 is a G protein-coupled receptor that plays an important part in the signaling pathway between cancer cells and tumor microenvironment. CXCR4 overexpression has been shown in a variety of cancers. In this study, we evaluate the potential value of [

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Publisher

Elsevier

Journal

European Journal of Radiology

scimago Q1

SJR

0.976

CiteScore

6.7

Impact factor

3.2

ISSN

0720048X (Print)

18727727 (Electronic)