Elsevier
Epilepsy Research
,  volume 210 ,  pages 107510

Significant reduction of seizure frequency in patients with drug-resistant epilepsy by vagus nerve stimulation: Systematic review and meta-analysis

Malaisamy Muniyandi 1
, 
Karthick Chelvanayagam 1
, 
Sahil Abdul Salam 1
, 
Sathishkumar Vadamalai 1
, 
Kavitha Rajsekar 2
, 
Rajeswari Ramachandran 3
1
 
2
 
Department of Health Research, Ministry of Health and Family Welfare, New Delhi, India | 
3
 
Consultant Neurologist, Dr. Kamakshi Memorial Hospital, Chennai, India | 
Publication type: Journal Article
Publication date: 2025-02-01
Elsevier
scimago Q2
wos Q3
SJR: 0.694
CiteScore: 4.4
Impact factor: 2.0
ISSN: 09201211, 18726844
Abstract
BackgroundEpilepsy is a major neurological disorder, typically managed with Anti-Seizure Medication (ASM). Nevertheless, a substantial 30 % of patients did not respond satisfactorily to ASMs, classifying their condition as Drug-Resistant Epilepsy (DRE). Vagus Nerve Stimulation (VNS) was recommended as a potential solution.
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Muniyandi M. et al. Significant reduction of seizure frequency in patients with drug-resistant epilepsy by vagus nerve stimulation: Systematic review and meta-analysis // Epilepsy Research. 2025. Vol. 210. p. 107510.
GOST all authors (up to 50) Copy
Muniyandi M., Chelvanayagam K., Salam S. A., Vadamalai S., Rajsekar K., Ramachandran R. Significant reduction of seizure frequency in patients with drug-resistant epilepsy by vagus nerve stimulation: Systematic review and meta-analysis // Epilepsy Research. 2025. Vol. 210. p. 107510.
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RIS Copy
TY - JOUR
DO - 10.1016/j.eplepsyres.2025.107510
UR - https://linkinghub.elsevier.com/retrieve/pii/S0920121125000117
TI - Significant reduction of seizure frequency in patients with drug-resistant epilepsy by vagus nerve stimulation: Systematic review and meta-analysis
T2 - Epilepsy Research
AU - Muniyandi, Malaisamy
AU - Chelvanayagam, Karthick
AU - Salam, Sahil Abdul
AU - Vadamalai, Sathishkumar
AU - Rajsekar, Kavitha
AU - Ramachandran, Rajeswari
PY - 2025
DA - 2025/02/01
PB - Elsevier
SP - 107510
VL - 210
SN - 0920-1211
SN - 1872-6844
ER -
BibTex
Cite this
BibTex (up to 50 authors) Copy
@article{2025_Muniyandi,
author = {Malaisamy Muniyandi and Karthick Chelvanayagam and Sahil Abdul Salam and Sathishkumar Vadamalai and Kavitha Rajsekar and Rajeswari Ramachandran},
title = {Significant reduction of seizure frequency in patients with drug-resistant epilepsy by vagus nerve stimulation: Systematic review and meta-analysis},
journal = {Epilepsy Research},
year = {2025},
volume = {210},
publisher = {Elsevier},
month = {feb},
url = {https://linkinghub.elsevier.com/retrieve/pii/S0920121125000117},
pages = {107510},
doi = {10.1016/j.eplepsyres.2025.107510}
}