Identification of p38MAPK-dependent genes with changed transcript abundance in H2O2-induced premature senescence of IMR-90 hTERT human fibroblasts
2
Eppendorf Array Technologies, Rue du Seminaire, 22 B-5000 Namur, Belgium
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Publication type: Journal Article
Publication date: 2006-11-07
scimago Q1
wos Q2
SJR: 1.222
CiteScore: 6.1
Impact factor: 3.0
ISSN: 00145793, 18733468
PubMed ID:
17101135
Biochemistry
Molecular Biology
Cell Biology
Genetics
Structural Biology
Biophysics
Abstract
Premature senescence of IMR-90 human diploid fibroblasts expressing telomerase (hTERT) establishes after exposure to an acute sublethal concentration of H2O2. We showed herein that p38(MAPK) was phosphorylated after exposure of IMR-90 hTERT cells to H2O2. Selective inhibition of p38(MAPK) activity attenuated the increase in the proportion of cells positive for senescence associated beta-galactosidase activity. We generated a low density DNA array to study gene expression profiles of 240 senescence-related genes. Using this array, p38(MAPK) inhibitor and p38(MAPK) small interferent RNA, we identified several p38(MAPK)-target genes differentially expressed in H2O2-stressed IMR-90 hTERT fibroblasts.
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GOST
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Zdanov S. et al. Identification of p38MAPK-dependent genes with changed transcript abundance in H2O2-induced premature senescence of IMR-90 hTERT human fibroblasts // FEBS Letters. 2006. Vol. 580. No. 27. pp. 6455-6463.
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Zdanov S., Debacq-Chainiaux F., Remacle J., Toussaint O. Identification of p38MAPK-dependent genes with changed transcript abundance in H2O2-induced premature senescence of IMR-90 hTERT human fibroblasts // FEBS Letters. 2006. Vol. 580. No. 27. pp. 6455-6463.
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RIS
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TY - JOUR
DO - 10.1016/j.febslet.2006.10.064
UR - https://doi.org/10.1016/j.febslet.2006.10.064
TI - Identification of p38MAPK-dependent genes with changed transcript abundance in H2O2-induced premature senescence of IMR-90 hTERT human fibroblasts
T2 - FEBS Letters
AU - Zdanov, Stephanie
AU - Debacq-Chainiaux, Florence
AU - Remacle, José
AU - Toussaint, Olivier
PY - 2006
DA - 2006/11/07
PB - Wiley
SP - 6455-6463
IS - 27
VL - 580
PMID - 17101135
SN - 0014-5793
SN - 1873-3468
ER -
Cite this
BibTex (up to 50 authors)
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@article{2006_Zdanov,
author = {Stephanie Zdanov and Florence Debacq-Chainiaux and José Remacle and Olivier Toussaint},
title = {Identification of p38MAPK-dependent genes with changed transcript abundance in H2O2-induced premature senescence of IMR-90 hTERT human fibroblasts},
journal = {FEBS Letters},
year = {2006},
volume = {580},
publisher = {Wiley},
month = {nov},
url = {https://doi.org/10.1016/j.febslet.2006.10.064},
number = {27},
pages = {6455--6463},
doi = {10.1016/j.febslet.2006.10.064}
}
Cite this
MLA
Copy
Zdanov, Stephanie, et al. “Identification of p38MAPK-dependent genes with changed transcript abundance in H2O2-induced premature senescence of IMR-90 hTERT human fibroblasts.” FEBS Letters, vol. 580, no. 27, Nov. 2006, pp. 6455-6463. https://doi.org/10.1016/j.febslet.2006.10.064.