Neuroprotective and antioxidant lanostanoid triterpenes from the fruiting bodies of Ganoderma atrum
1
Department of Internal Neurology, Benxi Central Hospital, Benxi 117000, PR China
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2
Department of Pharmaceutics, The 98th Hospital of PLA, Huzhou 313000, PR China.
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Publication type: Journal Article
Publication date: 2016-03-01
scimago Q2
wos Q3
SJR: 0.537
CiteScore: 3.9
Impact factor: 2.6
ISSN: 0367326X, 18736971
PubMed ID:
26709153
Drug Discovery
General Medicine
Pharmacology
Abstract
Five new lanostanoid triterpenes were isolated from the ethanol extract of the fruiting bodies of Ganoderma atrum. The structures of the isolated compounds were established based on 1D and 2D ((1)H-(1)H COSY, HMQC, and HMBC) NMR spectroscopy, in addition to high resolution mass spectrometry. The isolated compounds were tested in vitro for neuroprotective activities against 6-OHDA-induced cell death in SH-SY5Y cells and radical scavenging activities. As a result, compounds 2 and 5 exhibited potent neuroprotective activity against 6-OHDA-induced cell death in SH-SY5Y cells with the lowest IC50 value (0.5 μM) while compounds 1, 3 and 4 possessed significant neuroprotective activity with IC50 value less than 10 μM. Additionally, all tested compounds 1-6 showed the comparable free radical scavenging activities with the standard drug trolox in both ABTS (+) and DPPH experiment.
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QIU J., Wang X., Song C. Neuroprotective and antioxidant lanostanoid triterpenes from the fruiting bodies of Ganoderma atrum // Fitoterapia. 2016. Vol. 109. pp. 75-79.
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QIU J., Wang X., Song C. Neuroprotective and antioxidant lanostanoid triterpenes from the fruiting bodies of Ganoderma atrum // Fitoterapia. 2016. Vol. 109. pp. 75-79.
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TY - JOUR
DO - 10.1016/j.fitote.2015.12.008
UR - https://doi.org/10.1016/j.fitote.2015.12.008
TI - Neuroprotective and antioxidant lanostanoid triterpenes from the fruiting bodies of Ganoderma atrum
T2 - Fitoterapia
AU - QIU, JUNMING
AU - Wang, Xiang
AU - Song, Chengguang
PY - 2016
DA - 2016/03/01
PB - Elsevier
SP - 75-79
VL - 109
PMID - 26709153
SN - 0367-326X
SN - 1873-6971
ER -
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BibTex (up to 50 authors)
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@article{2016_QIU,
author = {JUNMING QIU and Xiang Wang and Chengguang Song},
title = {Neuroprotective and antioxidant lanostanoid triterpenes from the fruiting bodies of Ganoderma atrum},
journal = {Fitoterapia},
year = {2016},
volume = {109},
publisher = {Elsevier},
month = {mar},
url = {https://doi.org/10.1016/j.fitote.2015.12.008},
pages = {75--79},
doi = {10.1016/j.fitote.2015.12.008}
}