Two novel nornemoralisin-type diterpenoids from Aphanamixis polystachya (Wall.) R. Parker
Publication type: Journal Article
Publication date: 2020-01-01
scimago Q2
wos Q3
SJR: 0.537
CiteScore: 3.9
Impact factor: 2.6
ISSN: 0367326X, 18736971
PubMed ID:
31759031
Drug Discovery
General Medicine
Pharmacology
Abstract
Two novel heptanornemoralisin-type diterpenoids nornemoralisins A (1) and B (2), together with two known compounds nemoralisin (3) and nemoralisin A (4), were isolated from the stem bark and leaves of Aphanamixis polystachya (Wall.) R. Parker. Their structures were established through comprehensive analyses of NMR spectroscopic data and high resolution mass spectrometric (HR-ESI-MS) data. The absolute configurations of carbon stereocenters were elucidated by circular dichroism (CD) analyses. The four compounds were tested for their potential cytotoxic effects against ACHN, HeLa, SMMC-7721, and MCF-7 cell lines. Nornemoralisins A (1) and B (2) exhibited significant cytotoxicity on ACHN with an IC50 value of 13.9 ± 0.8 and 10.3 ± 0.4 μM, respectively, and other compounds failed to reveal obvious cytotoxicity on the tested cell lines, compared to positive control vinblastine (IC50, 28.0 ± 0.9 μM).
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Wu X. Z. et al. Two novel nornemoralisin-type diterpenoids from Aphanamixis polystachya (Wall.) R. Parker // Fitoterapia. 2020. Vol. 140. p. 104431.
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Wu X. Z., Fang F. H., Huang W. J., Shi Y., Pan H. Q., Lu N., Yuan C. Two novel nornemoralisin-type diterpenoids from Aphanamixis polystachya (Wall.) R. Parker // Fitoterapia. 2020. Vol. 140. p. 104431.
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TY - JOUR
DO - 10.1016/j.fitote.2019.104431
UR - https://doi.org/10.1016/j.fitote.2019.104431
TI - Two novel nornemoralisin-type diterpenoids from Aphanamixis polystachya (Wall.) R. Parker
T2 - Fitoterapia
AU - Wu, Xiao Zhen
AU - Fang, Fu Hu
AU - Huang, Wen Jun
AU - Shi, Ying-ying
AU - Pan, Hong Qian
AU - Lu, Ning
AU - Yuan, Cheng-Shan
PY - 2020
DA - 2020/01/01
PB - Elsevier
SP - 104431
VL - 140
PMID - 31759031
SN - 0367-326X
SN - 1873-6971
ER -
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@article{2020_Wu,
author = {Xiao Zhen Wu and Fu Hu Fang and Wen Jun Huang and Ying-ying Shi and Hong Qian Pan and Ning Lu and Cheng-Shan Yuan},
title = {Two novel nornemoralisin-type diterpenoids from Aphanamixis polystachya (Wall.) R. Parker},
journal = {Fitoterapia},
year = {2020},
volume = {140},
publisher = {Elsevier},
month = {jan},
url = {https://doi.org/10.1016/j.fitote.2019.104431},
pages = {104431},
doi = {10.1016/j.fitote.2019.104431}
}