The hydroxytyrosol-typed phenylpropanoidglycosides: A phenylpropanoid glycoside family with significant biological activity

Hydroxytyrosol-typed phenylpropanoid glycosides (HPGs), composed of phenylethanol and various complex oligosaccharides, are widespread and abundant in different plant, and have a diverse range of biological activities. All HPGs reported previously have been isolated from natural sources, and most of them showed significant bioactivities, such as anti-inflamatory, anti-cancer, cytoprotection, neuro-protective effects, enzyme-inhibitory, anti-microbial effects, and cardiovascular activity. The goal of this review is to summarize the structures of HPGs reported over the past few decades, as well as to introduce their pharmacological effects. We also introduce the possible relationship between the structures of HPGs and their source plants, as well as the structure-activity relationships of some important activities. This review will serve as a resource for future research into this class of compounds, and demonstrate their potential value.