Danggui Buxue decoction alleviates primary dysmenorrhea in rats by regulating the MEK1/2/ERK1/2/NF-κB pathway
Shi-Jia Gao
1, 2
,
Xiao-Li Li
2
,
Xiao Li Li
1
,
Rui Gao
2
,
Rui Ping Gao
1
,
Wen-Hong Tan
1, 2
,
Li Wen
3
,
Lu Liu
4
1
College of Tiaditional Chinese Medicine, Ynnan University of Chinese Medicine, Kunming 650500, China.
|
2
College of Tiaditional Chinese Medicine, Ynnan University of Chinese Medicine, Kunming 650500, China
|
4
College of Tiaditional Chinese Medicine, Ynnan University of Chinese Medicine, Kunming 650500, China. Electronic address: todayliulu@163.com.
|
Publication type: Journal Article
Publication date: 2025-01-01
scimago Q2
wos Q3
SJR: 0.537
CiteScore: 3.9
Impact factor: 2.6
ISSN: 0367326X, 18736971
PubMed ID:
39615702
Abstract
The study aimed to investigate the efficacy of Danggui Buxue Decoction (DBD) in treating primary dysmenorrhea (PD) and uncover its mechanisms, thereby validating its traditional use. Using ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS), 38 compounds in DBD were identified. PD model rats were established via cold stimulation, estradiol benzoate, and oxytocin injections. DBD treatment improved behavioral parameters, reduced writhing response, and alleviated histopathological changes in uterus and ovary. Biochemical markers (PGE2, SOD and MDA, among others) were assessed using ELISA, and Western blot was employed to analyze protein levels in rat uteri. Results showed that DBD modulated these proteins, indicating its protective effects. The study provides scientific evidence for DBD's role in nourishing “qi” or enriching “blood” during PD treatment by affecting the MEK1/2/ERK1/2/NF-κB signaling pathway, thus reducing oxidative stress and proinflammatory factors in PD rats.
Found
Nothing found, try to update filter.
Found
Nothing found, try to update filter.
Top-30
Journals
|
1
|
|
|
Frontiers in Pharmacology
1 publication, 33.33%
|
|
|
Frontiers in Medicine
1 publication, 33.33%
|
|
|
Acupuncture and Electro-Therapeutics Research
1 publication, 33.33%
|
|
|
1
|
Publishers
|
1
2
|
|
|
Frontiers Media S.A.
2 publications, 66.67%
|
|
|
Cognizant, LLC
1 publication, 33.33%
|
|
|
1
2
|
- We do not take into account publications without a DOI.
- Statistics recalculated weekly.
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
3
Total citations:
3
Citations from 2024:
3
(100%)
Cite this
GOST |
RIS |
BibTex
Cite this
GOST
Copy
Gao S. et al. Danggui Buxue decoction alleviates primary dysmenorrhea in rats by regulating the MEK1/2/ERK1/2/NF-κB pathway // Fitoterapia. 2025. Vol. 180. p. 106315.
GOST all authors (up to 50)
Copy
Gao S., Li X., Li X. L., Gao R., Gao R. P., Tan W., Wen L., Liu L. Danggui Buxue decoction alleviates primary dysmenorrhea in rats by regulating the MEK1/2/ERK1/2/NF-κB pathway // Fitoterapia. 2025. Vol. 180. p. 106315.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.fitote.2024.106315
UR - https://linkinghub.elsevier.com/retrieve/pii/S0367326X24004982
TI - Danggui Buxue decoction alleviates primary dysmenorrhea in rats by regulating the MEK1/2/ERK1/2/NF-κB pathway
T2 - Fitoterapia
AU - Gao, Shi-Jia
AU - Li, Xiao-Li
AU - Li, Xiao Li
AU - Gao, Rui
AU - Gao, Rui Ping
AU - Tan, Wen-Hong
AU - Wen, Li
AU - Liu, Lu
PY - 2025
DA - 2025/01/01
PB - Elsevier
SP - 106315
VL - 180
PMID - 39615702
SN - 0367-326X
SN - 1873-6971
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2025_Gao,
author = {Shi-Jia Gao and Xiao-Li Li and Xiao Li Li and Rui Gao and Rui Ping Gao and Wen-Hong Tan and Li Wen and Lu Liu},
title = {Danggui Buxue decoction alleviates primary dysmenorrhea in rats by regulating the MEK1/2/ERK1/2/NF-κB pathway},
journal = {Fitoterapia},
year = {2025},
volume = {180},
publisher = {Elsevier},
month = {jan},
url = {https://linkinghub.elsevier.com/retrieve/pii/S0367326X24004982},
pages = {106315},
doi = {10.1016/j.fitote.2024.106315}
}