C2C12 myoblasts differentiate into myofibroblasts via the TGF-β1 signaling pathway mediated by Fibulin2
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Publication type: Journal Article
Publication date: 2025-02-01
scimago Q2
wos Q3
SJR: 0.682
CiteScore: 5.1
Impact factor: 2.4
ISSN: 03781119, 18790038
PubMed ID:
39490650
Abstract
Myoblasts play a critical role in the regeneration of skeletal muscle following injury. It has been reported that local elevation of transforming growth factor-β1 (TGF-β1) after skeletal muscle injury induces differentiation of myoblasts into myofibroblasts. However, the mechanisms underlying this differentiation process remain incompletely understood. In this study, we found that Fibulin2 expression significantly increases in myoblasts in response to TGF-β1 stimulation. Elevated Fibulin2 levels enhance the expression of fibrotic markers. Conversely, downregulation of Fibulin2 in myoblasts inhibits the upregulation of fibrotic markers induced by TGF-β1 stimulation. Extracellular secretion of Fibulin2 activates the TGF-β1-Smad2 pathway, thereby promoting the upregulation of fibrotic markers. Hence, Fibulin2 and TGF-β1 form a positive feedback loop that facilitates differentiation of myoblasts into myofibroblasts.
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Total citations:
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Citations from 2024:
3
(100%)
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Yang Y. et al. C2C12 myoblasts differentiate into myofibroblasts via the TGF-β1 signaling pathway mediated by Fibulin2 // Gene. 2025. Vol. 936. p. 149048.
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Yang Y., Li L., Fei J., Li Z. C2C12 myoblasts differentiate into myofibroblasts via the TGF-β1 signaling pathway mediated by Fibulin2 // Gene. 2025. Vol. 936. p. 149048.
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TY - JOUR
DO - 10.1016/j.gene.2024.149048
UR - https://linkinghub.elsevier.com/retrieve/pii/S0378111924009296
TI - C2C12 myoblasts differentiate into myofibroblasts via the TGF-β1 signaling pathway mediated by Fibulin2
T2 - Gene
AU - Yang, Yongqiang
AU - Li, Lei
AU - Fei, Jun
AU - Li, Zhong
PY - 2025
DA - 2025/02/01
PB - Elsevier
SP - 149048
VL - 936
PMID - 39490650
SN - 0378-1119
SN - 1879-0038
ER -
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BibTex (up to 50 authors)
Copy
@article{2025_Yang,
author = {Yongqiang Yang and Lei Li and Jun Fei and Zhong Li},
title = {C2C12 myoblasts differentiate into myofibroblasts via the TGF-β1 signaling pathway mediated by Fibulin2},
journal = {Gene},
year = {2025},
volume = {936},
publisher = {Elsevier},
month = {feb},
url = {https://linkinghub.elsevier.com/retrieve/pii/S0378111924009296},
pages = {149048},
doi = {10.1016/j.gene.2024.149048}
}