Open Access
Electrochemically mediated three-component synthesis of isothioureas using thiols as sulfur source
Publication type: Journal Article
Publication date: 2023-02-01
scimago Q1
wos Q1
SJR: 1.444
CiteScore: 14.6
Impact factor: 6.3
ISSN: 26665549
Catalysis
Biotechnology
Abstract
The simultaneous binding/dissociation of multiple bonds in a one-pot manner by multicomponent reactions provide an important approach for developing novel and sustainable pathway in the drug discovery process. Herein we develop an electrocatalytic three-component reaction to construct multifunctional and valuable isothiourea compounds, which uses thiols, isocyanides and amines as substrates. Compared with the previous work, the organic electrosynthesis technique can avoid the requirement of heavy metal catalysts and stoichiometric oxidants. In addition, using thiol as a substrate to participate in the three-component reaction broadens the source of sulfur, which can also construct more abundant isothiourea derivatives. As an important synthetic intermediate, isothiourea plays a key role in the fields of agriculture and medicine. We reported an electrocatalytic three-component reaction to construct multifunctional and valuable isothiourea derivatives, which uses thiols, isocyanides and amines as substrates.
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Metrics
33
Total citations:
33
Citations from 2024:
15
(46.88%)
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MLA
Cite this
GOST
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He M. X. et al. Electrochemically mediated three-component synthesis of isothioureas using thiols as sulfur source // Green Synthesis and Catalysis. 2023. Vol. 4. No. 1. pp. 41-45.
GOST all authors (up to 50)
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He M. X., Zhong P., Liu H., Ou C., Pan Y., Tang H. Electrochemically mediated three-component synthesis of isothioureas using thiols as sulfur source // Green Synthesis and Catalysis. 2023. Vol. 4. No. 1. pp. 41-45.
Cite this
RIS
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TY - JOUR
DO - 10.1016/j.gresc.2022.03.002
UR - https://doi.org/10.1016/j.gresc.2022.03.002
TI - Electrochemically mediated three-component synthesis of isothioureas using thiols as sulfur source
T2 - Green Synthesis and Catalysis
AU - He, Mu Xue
AU - Zhong, Pingfu
AU - Liu, Hanfu
AU - Ou, Chuhong
AU - Pan, Yingming
AU - Tang, Haitao
PY - 2023
DA - 2023/02/01
PB - Elsevier
SP - 41-45
IS - 1
VL - 4
SN - 2666-5549
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2023_He,
author = {Mu Xue He and Pingfu Zhong and Hanfu Liu and Chuhong Ou and Yingming Pan and Haitao Tang},
title = {Electrochemically mediated three-component synthesis of isothioureas using thiols as sulfur source},
journal = {Green Synthesis and Catalysis},
year = {2023},
volume = {4},
publisher = {Elsevier},
month = {feb},
url = {https://doi.org/10.1016/j.gresc.2022.03.002},
number = {1},
pages = {41--45},
doi = {10.1016/j.gresc.2022.03.002}
}
Cite this
MLA
Copy
He, Mu Xue, et al. “Electrochemically mediated three-component synthesis of isothioureas using thiols as sulfur source.” Green Synthesis and Catalysis, vol. 4, no. 1, Feb. 2023, pp. 41-45. https://doi.org/10.1016/j.gresc.2022.03.002.
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