Open Access
The role, relevance and management of immune exhaustion in bovine infectious diseases
Shalini Sharma
1, 2
,
Naveen Kumar
3, 4
,
Barry T. Rouse
5, 6
,
Kunal Sharma
1
,
Khushbu Sharma
2
,
Kundan Kumar Chaubey
7
,
Sanjiv Singh
8
,
Shoorvir Singh
9
,
Shoor Vir Singh
9
,
Praveen Kumar
10, 11
,
Pankaj Kumar
10
,
Pradeep Kumar
11
3
National Center for Veterinary Type Cultures, ICAR-NRC on Equines, Sirsa Road, Hisar, Haryana, 125001, India.
|
4
National Center for Veterinary Type Cultures, ICAR-NRC on Equines, Sirsa Road, Hisar, Haryana, 125001, India
|
7
Department of Biotechnology, School of Basic and Applied Sciences, Sanskriti University, Mathura, Uttar Pradesh, 281 401, India
|
Publication type: Journal Article
Publication date: 2024-04-01
PubMed ID:
38596123
Multidisciplinary
Abstract
Immune exhaustion is a state of immune cell dysfunction that occurs most commonly following chronic exposure to an antigen which persists after the immune response fails to remove it. Exhaustion has been studied most thoroughly with several cancers, but has also been observed in several chronic infectious diseases. The topic has mainly been studied with CD8+ T cells, but it can also occur with CD4+ T cells and other immune cell types too. Exhaustion is characterized by a hierarchical loss of effector cell functions, up-regulation of immuno-inhibitory receptors, disruption of metabolic activities, and altered chromatin landscapes. Exhaustion has received minimal attention so far in diseases of veterinary significance and this review's purpose is to describe examples where immune exhaustion is occurring in several bovine disease situations. We also describe methodology to evaluate immune exhaustion as well as the prospects of controlling exhaustion and achieving a more suitable outcome of therapy in some chronic disease scenarios.
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Total citations:
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Citations from 2024:
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(100%)
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GOST
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Sharma S. et al. The role, relevance and management of immune exhaustion in bovine infectious diseases // Heliyon. 2024. Vol. 10. No. 7. p. e28663.
GOST all authors (up to 50)
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Sharma S., Kumar N., Rouse B. T., Sharma K., Sharma K., Chaubey K. K., Singh S., Singh S., Singh S. V., Kumar P., Kumar P., Kumar P. The role, relevance and management of immune exhaustion in bovine infectious diseases // Heliyon. 2024. Vol. 10. No. 7. p. e28663.
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RIS
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TY - JOUR
DO - 10.1016/j.heliyon.2024.e28663
UR - https://linkinghub.elsevier.com/retrieve/pii/S2405844024046942
TI - The role, relevance and management of immune exhaustion in bovine infectious diseases
T2 - Heliyon
AU - Sharma, Shalini
AU - Kumar, Naveen
AU - Rouse, Barry T.
AU - Sharma, Kunal
AU - Sharma, Khushbu
AU - Chaubey, Kundan Kumar
AU - Singh, Sanjiv
AU - Singh, Shoorvir
AU - Singh, Shoor Vir
AU - Kumar, Praveen
AU - Kumar, Pankaj
AU - Kumar, Pradeep
PY - 2024
DA - 2024/04/01
PB - Elsevier
SP - e28663
IS - 7
VL - 10
PMID - 38596123
SN - 2405-8440
ER -
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BibTex (up to 50 authors)
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@article{2024_Sharma,
author = {Shalini Sharma and Naveen Kumar and Barry T. Rouse and Kunal Sharma and Khushbu Sharma and Kundan Kumar Chaubey and Sanjiv Singh and Shoorvir Singh and Shoor Vir Singh and Praveen Kumar and Pankaj Kumar and Pradeep Kumar},
title = {The role, relevance and management of immune exhaustion in bovine infectious diseases},
journal = {Heliyon},
year = {2024},
volume = {10},
publisher = {Elsevier},
month = {apr},
url = {https://linkinghub.elsevier.com/retrieve/pii/S2405844024046942},
number = {7},
pages = {e28663},
doi = {10.1016/j.heliyon.2024.e28663}
}
Cite this
MLA
Copy
Sharma, Shalini, et al. “The role, relevance and management of immune exhaustion in bovine infectious diseases.” Heliyon, vol. 10, no. 7, Apr. 2024, p. e28663. https://linkinghub.elsevier.com/retrieve/pii/S2405844024046942.