Open Access
Open access
Elsevier
IBRO Neuroscience Reports
,  volume 15 ,  pages 50-56

Acute sub-diaphragmatic anterior vagus nerve stimulation increases peripheral glucose uptake in anaesthetized rats

Publication type: Journal Article
Publication date: 2023-12-01
Elsevier
scimago Q3
wos Q2
SJR: 0.740
CiteScore: 3.4
Impact factor: 2.9
ISSN: 26672421
General Neuroscience
Abstract
The sub-diaphragmatic vagus innervates various organs involved in the control of glucose homeostasis including the liver, pancreas and the intestines. In the current study, we investigated the effect of acute electrical stimulation of the anterior trunk of the sub-diaphragmatic vagus on glucose fluxes in anaesthetized adult male rats. After overnight fast, rats underwent either vagus nerve stimulation (VNS+, n=11; rectangular pulses at 5 Hz, 1.5 mA, 1 msec pulse width) or sham stimulation (VNS-; n=11) for 120 minutes under isoflurane anesthesia. Before stimulation, the rats received an i.v. bolus of stable isotope labelled glucose [6,6-2H2]glucose. Endogenous glucose production (EGP) and glucose clearance rate (GCR) were calculated by kinetic analysis from the wash-out of injected D-[6,6-2H2]glucose from the circulation. VNS+ resulted in lower glucose levels compared to the VNS- group (p<0.05), with similar insulin levels. EGP was similar in both groups, but the GCR was higher in the VNS+ group compared to the VNS- group (p<0.001). Circulating levels of the sympathetic transmitter norepinephrine were reduced by VNS+ relative to VNS- treatment (p<0.01). It is concluded that acute anterior sub-diaphragmatic VNS causes stimulation of peripheral glucose uptake, while plasma insulin levels remained similar, and this is associated with lower activity of the sympathetic nervous system. Data will be made available on request
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Hoornenborg C. W. et al. Acute sub-diaphragmatic anterior vagus nerve stimulation increases peripheral glucose uptake in anaesthetized rats // IBRO Neuroscience Reports. 2023. Vol. 15. pp. 50-56.
GOST all authors (up to 50) Copy
Hoornenborg C. W., van Dijk T. H., Bruggink J., Van Beek A. P., van Dijk G. Acute sub-diaphragmatic anterior vagus nerve stimulation increases peripheral glucose uptake in anaesthetized rats // IBRO Neuroscience Reports. 2023. Vol. 15. pp. 50-56.
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RIS Copy
TY - JOUR
DO - 10.1016/j.ibneur.2023.06.005
UR - https://doi.org/10.1016/j.ibneur.2023.06.005
TI - Acute sub-diaphragmatic anterior vagus nerve stimulation increases peripheral glucose uptake in anaesthetized rats
T2 - IBRO Neuroscience Reports
AU - Hoornenborg, C W
AU - van Dijk, Theo H.
AU - Bruggink, J.E.
AU - Van Beek, A P
AU - van Dijk, G.
PY - 2023
DA - 2023/12/01
PB - Elsevier
SP - 50-56
VL - 15
PMID - 37415729
SN - 2667-2421
ER -
BibTex
Cite this
BibTex (up to 50 authors) Copy
@article{2023_Hoornenborg,
author = {C W Hoornenborg and Theo H. van Dijk and J.E. Bruggink and A P Van Beek and G. van Dijk},
title = {Acute sub-diaphragmatic anterior vagus nerve stimulation increases peripheral glucose uptake in anaesthetized rats},
journal = {IBRO Neuroscience Reports},
year = {2023},
volume = {15},
publisher = {Elsevier},
month = {dec},
url = {https://doi.org/10.1016/j.ibneur.2023.06.005},
pages = {50--56},
doi = {10.1016/j.ibneur.2023.06.005}
}