Elsevier
International Journal of Antimicrobial Agents
,  том 66 ,  издание 3 ,  страницы 107548

Isopentyl Caffeate Targets Gp63 (Leishmanolysin) in Leishmania amazonensis

Wanessa Santana Mota 1
, 
Simone S C Oliveira 2
, 
Agenor G. dos Santos-Neto 1
, 
Damião P. Souza 3
, 
Mayara Castro de Morais 3
, 
Matheus M. Pereira 4
, 
Sona Jain 5
, 
Juliana C Cardoso 1, 6
, 
Eliana B. Souto 7
, 
Patrícia Severino 1, 6
, 
André L.S Santos 2
1
 
Institute of Technology and Research, Farolândia, Aracaju, Sergipe, Brazil | 
2
 
3
 
4
 
5
 
6
 
7
 
Тип публикации: Journal Article
Дата публикации: 2025-09-01
Elsevier
scimago Q1
wos Q1
БС1
SJR: 0.955
CiteScore: 5.8
Impact factor: 4.6
ISSN: 09248579, 18727913
Краткое описание
ObjectivesSeveral drugs are commonly used in the management of Leishmaniasis, but their toxicity, cost, and efficacy depend on the form of the disease.The development of new therapeutics remains important to expand treatment options and address existing limitations. Previously, we reported that isopentyl caffeate (ICaf) exhibited potent activity against promastigotes and amastigotes of Leishmania amazonensis without notable toxicity in a murine model. This study investigated the effects of ICaf on the metallopeptidase gp63 (leishmanolysin), a key virulence factor in Leishmania that supports parasite survival by modulating host immune responses, degrading host proteins, and facilitating macrophage invasion.
Найдено 

Вы ученый?

Создайте профиль, чтобы получать персональные рекомендации коллег, конференций и новых статей.
Метрики
0
Поделиться
Цитировать
ГОСТ |
Цитировать
ГОСТ Скопировать
Santana Mota W. et al. Isopentyl Caffeate Targets Gp63 (Leishmanolysin) in Leishmania amazonensis // International Journal of Antimicrobial Agents. 2025. Vol. 66. No. 3. p. 107548.
ГОСТ со всеми авторами (до 50) Скопировать
Santana Mota W., Oliveira S. S. C., dos Santos-Neto A. G., Souza D. P., de Morais M. C., Pereira M. M., Jain S., Cardoso J. C., Souto E. B., Severino P., Santos A. L. Isopentyl Caffeate Targets Gp63 (Leishmanolysin) in Leishmania amazonensis // International Journal of Antimicrobial Agents. 2025. Vol. 66. No. 3. p. 107548.
RIS |
Цитировать
RIS Скопировать
TY - JOUR
DO - 10.1016/j.ijantimicag.2025.107548
UR - https://linkinghub.elsevier.com/retrieve/pii/S0924857925001050
TI - Isopentyl Caffeate Targets Gp63 (Leishmanolysin) in Leishmania amazonensis
T2 - International Journal of Antimicrobial Agents
AU - Santana Mota, Wanessa
AU - Oliveira, Simone S C
AU - dos Santos-Neto, Agenor G.
AU - Souza, Damião P.
AU - de Morais, Mayara Castro
AU - Pereira, Matheus M.
AU - Jain, Sona
AU - Cardoso, Juliana C
AU - Souto, Eliana B.
AU - Severino, Patrícia
AU - Santos, André L.S
PY - 2025
DA - 2025/09/01
PB - Elsevier
SP - 107548
IS - 3
VL - 66
SN - 0924-8579
SN - 1872-7913
ER -
BibTex |
Цитировать
BibTex (до 50 авторов) Скопировать
@article{2025_Santana Mota,
author = {Wanessa Santana Mota and Simone S C Oliveira and Agenor G. dos Santos-Neto and Damião P. Souza and Mayara Castro de Morais and Matheus M. Pereira and Sona Jain and Juliana C Cardoso and Eliana B. Souto and Patrícia Severino and André L.S Santos},
title = {Isopentyl Caffeate Targets Gp63 (Leishmanolysin) in Leishmania amazonensis},
journal = {International Journal of Antimicrobial Agents},
year = {2025},
volume = {66},
publisher = {Elsevier},
month = {sep},
url = {https://linkinghub.elsevier.com/retrieve/pii/S0924857925001050},
number = {3},
pages = {107548},
doi = {10.1016/j.ijantimicag.2025.107548}
}
MLA
Цитировать
MLA Скопировать
Santana Mota, Wanessa, et al. “Isopentyl Caffeate Targets Gp63 (Leishmanolysin) in Leishmania amazonensis.” International Journal of Antimicrobial Agents, vol. 66, no. 3, Sep. 2025, p. 107548. https://linkinghub.elsevier.com/retrieve/pii/S0924857925001050.
Профили