The antibacterial and hemostatic curdlan hydrogel–loading epigallocatechin gallate for facilitating the infected wound healing
Qiang Ding
1, 2, 3, 4, 5
,
Zhendong Mo
6
,
XINYUE WANG
1, 2, 3, 4, 5
,
Xin Yue Wang
1, 2
,
Xin-Yue Wang
1, 2, 3, 4, 5
,
Meiling Chen
1, 2
,
Meiling Chen
1, 2, 3, 4, 5
,
Fan Zhou
1, 2
,
Fan Zhou
1, 2, 3, 4, 5
,
Zhengquan Liu
1, 2, 3, 4, 5
,
LONG YING
1, 2, 3, 4, 5
,
Ying Long
1, 2, 3, 4, 5
,
Xianzhu Xia
1, 7
,
Pingsen Zhao
1, 2, 3, 4, 5
2
Shaoguan Municipal Quality Control Center for Surveillance of Bacterial Resistance, Shaoguan 512025, China
|
4
Shaoguan Engineering Research Center for Research and Development of Molecular and Cellular Technology in Rapid Diagnosis of Infectious Diseases and Cancer, Shaoguan 512025, China
|
7
Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130122, China
|
Publication type: Journal Article
Publication date: 2024-05-01
scimago Q1
wos Q1
SJR: 1.285
CiteScore: 10.3
Impact factor: 8.5
ISSN: 01418130, 18790003
PubMed ID:
38554908
Biochemistry
Molecular Biology
General Medicine
Structural Biology
Abstract
The infected wounds pose one of the major threats to human health today. To address this issue, it is necessary to develop innovative wound dressings with superior antibacterial activity and other properties. Due to its potent antibacterial, antioxidant, and immune-boosting properties, epigallocatechin gallate (EGCG) has been widely utilized. In this study, a multifunctional curdlan hydrogel loading EGCG (Cur-EGCGH3) was designed. Cur-EGCGH3 exhibited excellent physicochemical properties, good biocompatibility, hemostatic, antibacterial, and antioxidant activities. Also, ELISA data showed that Cur-EGCGH3 stimulated macrophages to secrete pro-inflammatory and pro-regenerative cytokines. Cell scratch results indicated that Cur-EGCGH3 promoted the migration of NIH3T3 and HUVECs. In vivo experiments confirmed that Cur-EGCGH3 could inhibit bacterial infection of the infected wounds, accelerate hemostasis, and promote epithelial regeneration and collagen deposition. These results demonstrated that Cur-EGCGH3 holds promise for promoting healing of the infected wounds.
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Total citations:
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Citations from 2024:
7
(100%)
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Ding Q. et al. The antibacterial and hemostatic curdlan hydrogel–loading epigallocatechin gallate for facilitating the infected wound healing // International Journal of Biological Macromolecules. 2024. Vol. 266. No. Pt 1. p. 131257.
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Ding Q. et al. The antibacterial and hemostatic curdlan hydrogel–loading epigallocatechin gallate for facilitating the infected wound healing // International Journal of Biological Macromolecules. 2024. Vol. 266. No. Pt 1. p. 131257.
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TY - JOUR
DO - 10.1016/j.ijbiomac.2024.131257
UR - https://linkinghub.elsevier.com/retrieve/pii/S0141813024020622
TI - The antibacterial and hemostatic curdlan hydrogel–loading epigallocatechin gallate for facilitating the infected wound healing
T2 - International Journal of Biological Macromolecules
AU - Ding, Qiang
AU - Mo, Zhendong
AU - WANG, XINYUE
AU - Wang, Xin Yue
AU - Wang, Xin-Yue
AU - Chen, Meiling
AU - Chen, Meiling
AU - Zhou, Fan
AU - Zhou, Fan
AU - Liu, Zhengquan
AU - YING, LONG
AU - Long, Ying
AU - Xia, Xianzhu
AU - Zhao, Pingsen
PY - 2024
DA - 2024/05/01
PB - Elsevier
SP - 131257
IS - Pt 1
VL - 266
PMID - 38554908
SN - 0141-8130
SN - 1879-0003
ER -
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BibTex (up to 50 authors)
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@article{2024_Ding,
author = {Qiang Ding and Zhendong Mo and XINYUE WANG and Xin Yue Wang and Xin-Yue Wang and Meiling Chen and Meiling Chen and Fan Zhou and Fan Zhou and Zhengquan Liu and LONG YING and Ying Long and Xianzhu Xia and Pingsen Zhao and others},
title = {The antibacterial and hemostatic curdlan hydrogel–loading epigallocatechin gallate for facilitating the infected wound healing},
journal = {International Journal of Biological Macromolecules},
year = {2024},
volume = {266},
publisher = {Elsevier},
month = {may},
url = {https://linkinghub.elsevier.com/retrieve/pii/S0141813024020622},
number = {Pt 1},
pages = {131257},
doi = {10.1016/j.ijbiomac.2024.131257}
}
Cite this
MLA
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Ding, Qiang, et al. “The antibacterial and hemostatic curdlan hydrogel–loading epigallocatechin gallate for facilitating the infected wound healing.” International Journal of Biological Macromolecules, vol. 266, no. Pt 1, May. 2024, p. 131257. https://linkinghub.elsevier.com/retrieve/pii/S0141813024020622.