Open Access
Fatal thrombotic microangiopathy with rhabdomyolysis as an initial symptom after the first dose of mRNA–1273 vaccine: A case report
1
Division of Hematology/Oncology, Department of Internal Medicine, Kameda Medical Centre, 929 Higashi-cho, Kamogawa-shi, Chiba 296-8602, Japan.
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2
Division of Rheumatology, Department of Internal Medicine, Kameda Medical Centre.
3
Department of Intensive Care Medicine, Kameda Medical Centre.
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Department of Pathology, Kameda Medical Centre.
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Division of Hematology/Oncology, Department of Internal Medicine, Kameda Medical Centre, 929 Higashi-cho, Kamogawa-shi, Chiba 296-8602, Japan. Electronic address: koseimatsue@gmail.com.
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Publication type: Journal Article
Publication date: 2022-04-01
scimago Q1
wos Q1
SJR: 1.323
CiteScore: 12.6
Impact factor: 4.3
ISSN: 12019712, 18783511
PubMed ID:
35189339
General Medicine
Microbiology (medical)
Infectious Diseases
Abstract
We report a case of a Japanese man with severe rhabdomyolysis and multiple thrombosis of arterioles after the first dose of mRNA-1273 vaccine. He developed rapidly progressive rhabdomyolysis and infarctions of multiple organs. Antiplatelet factor 4 antibody test was negative. Despite the intensive supportive care, including aggressive fluid administration, hemodialysis, administration of anticoagulants, high-dose steroid, and eculizumab, the patient ultimately died of multiple organ failure. Autopsy revealed multiple thrombosis in the arterioles and organ necrosis. Low serum complements and C3 deposition in the renal glomeruli detected by immunofluorescence suggested a possible immune-mediated mechanism. To our knowledge, this is the first case report of rhabdomyolysis and multiple thrombosis of the arterioles as an adverse event following COVID-19 vaccination.
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Total citations:
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Citations from 2024:
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GOST
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Kamura Y. et al. Fatal thrombotic microangiopathy with rhabdomyolysis as an initial symptom after the first dose of mRNA–1273 vaccine: A case report // International Journal of Infectious Diseases. 2022. Vol. 117. pp. 322-325.
GOST all authors (up to 50)
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Kamura Y., Terao T., Akao S., Kono Y., Koichi H., Matsue K. Fatal thrombotic microangiopathy with rhabdomyolysis as an initial symptom after the first dose of mRNA–1273 vaccine: A case report // International Journal of Infectious Diseases. 2022. Vol. 117. pp. 322-325.
Cite this
RIS
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TY - JOUR
DO - 10.1016/j.ijid.2022.02.031
UR - https://doi.org/10.1016/j.ijid.2022.02.031
TI - Fatal thrombotic microangiopathy with rhabdomyolysis as an initial symptom after the first dose of mRNA–1273 vaccine: A case report
T2 - International Journal of Infectious Diseases
AU - Kamura, Yuya
AU - Terao, Toshiki
AU - Akao, Satoshi
AU - Kono, Yumi
AU - Koichi, Honma
AU - Matsue, Kosei
PY - 2022
DA - 2022/04/01
PB - Elsevier
SP - 322-325
VL - 117
PMID - 35189339
SN - 1201-9712
SN - 1878-3511
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2022_Kamura,
author = {Yuya Kamura and Toshiki Terao and Satoshi Akao and Yumi Kono and Honma Koichi and Kosei Matsue},
title = {Fatal thrombotic microangiopathy with rhabdomyolysis as an initial symptom after the first dose of mRNA–1273 vaccine: A case report},
journal = {International Journal of Infectious Diseases},
year = {2022},
volume = {117},
publisher = {Elsevier},
month = {apr},
url = {https://doi.org/10.1016/j.ijid.2022.02.031},
pages = {322--325},
doi = {10.1016/j.ijid.2022.02.031}
}