Open Access
Targeted Next Generation Sequencing (tNGS) for detection of drug-resistant tuberculous meningitis: Is this sequencing technology ready for prime time?
Priti Kambli
1
,
Kanchan Ajbani
2
,
Amala A. Andrews
3
,
Priya Ranganathan
4
,
Anjali Shetty
5
,
Anjali Shetty
5
,
Tanvi Patil
6
,
Ishita Mehta
7
,
Harpreet Singh
8
,
Camilla Rodrigues
9
1
Microbiology Section, Department of Laboratory Medicine, P.D. Hinduja National Hospital and Medical Research Centre, Mumbai, India. Electronic address: pritikambli03@gmail.com.
|
2
Microbiology Section, Department of Laboratory Medicine, P.D. Hinduja National Hospital and Medical Research Centre, Mumbai, India. Electronic address: k.ajbani03@gmail.com.
|
4
Microbiology Section, Department of Laboratory Medicine, P.D. Hinduja National Hospital and Medical Research Centre, Mumbai, India. Electronic address: dr_shaoli.basu@hindujahospital.com.
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5
Microbiology Section, Department of Laboratory Medicine, P.D. Hinduja National Hospital and Medical Research Centre, Mumbai, India. Electronic address: dr_ashetty@hindujahospital.com.
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6
ICMR-National Institute of Immunohematology, India. Electronic address: patil.tanvirc1630@gmail.com.
7
Lilac Insights Pvt Ltd, India. Electronic address: mehtaishita96@gmail.com.
8
Bioinformatics Section, Indian Council of Medical Research, New Delhi Area, India. Electronic address: hsingh@bmi.icmr.org.in.
|
9
Microbiology Section, Department of Laboratory Medicine, P.D. Hinduja National Hospital and Medical Research Centre, Mumbai, India. Electronic address: dr_crodrigues@hindujahospital.com.
|
Publication type: Journal Article
Publication date: 2024-09-01
scimago Q3
wos Q4
SJR: 0.366
CiteScore: 2.4
Impact factor: 1.3
ISSN: 02550857, 19983646
PubMed ID:
38986772
Abstract
Tuberculous meningitis (TBM) is the most severe form of tuberculosis (TB). Difficulty in diagnosing the condition along with other factors, increases its potential for high morbidity and mortality. Targeted Next Generation Sequencing (tNGS) generates high quality sequence read depths, enabling the identification of low-frequency alleles linked to Drug resistance (DR). The paucibacillary nature of tuberculous meningitis is a challenge for making a definitive diagnosis.
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Kambli P. et al. Targeted Next Generation Sequencing (tNGS) for detection of drug-resistant tuberculous meningitis: Is this sequencing technology ready for prime time? // Indian Journal of Medical Microbiology. 2024. Vol. 51. p. 100665.
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Kambli P., Ajbani K., Andrews A. A., Ranganathan P., Shetty A., Shetty A., Patil T., Mehta I., Singh H., Rodrigues C. Targeted Next Generation Sequencing (tNGS) for detection of drug-resistant tuberculous meningitis: Is this sequencing technology ready for prime time? // Indian Journal of Medical Microbiology. 2024. Vol. 51. p. 100665.
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TY - JOUR
DO - 10.1016/j.ijmmb.2024.100665
UR - https://linkinghub.elsevier.com/retrieve/pii/S0255085724001403
TI - Targeted Next Generation Sequencing (tNGS) for detection of drug-resistant tuberculous meningitis: Is this sequencing technology ready for prime time?
T2 - Indian Journal of Medical Microbiology
AU - Kambli, Priti
AU - Ajbani, Kanchan
AU - Andrews, Amala A.
AU - Ranganathan, Priya
AU - Shetty, Anjali
AU - Shetty, Anjali
AU - Patil, Tanvi
AU - Mehta, Ishita
AU - Singh, Harpreet
AU - Rodrigues, Camilla
PY - 2024
DA - 2024/09/01
PB - Elsevier
SP - 100665
VL - 51
PMID - 38986772
SN - 0255-0857
SN - 1998-3646
ER -
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@article{2024_Kambli,
author = {Priti Kambli and Kanchan Ajbani and Amala A. Andrews and Priya Ranganathan and Anjali Shetty and Anjali Shetty and Tanvi Patil and Ishita Mehta and Harpreet Singh and Camilla Rodrigues},
title = {Targeted Next Generation Sequencing (tNGS) for detection of drug-resistant tuberculous meningitis: Is this sequencing technology ready for prime time?},
journal = {Indian Journal of Medical Microbiology},
year = {2024},
volume = {51},
publisher = {Elsevier},
month = {sep},
url = {https://linkinghub.elsevier.com/retrieve/pii/S0255085724001403},
pages = {100665},
doi = {10.1016/j.ijmmb.2024.100665}
}
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