Distinct human Langerhans cell subsets orchestrate reciprocal functions and require different developmental regulation
Ronghui Zhu
1
,
Shangshang Wang
1
,
Yi Zhao
2
,
Zhuoqiong Qiu
1
,
Xiao Liu
3
,
Xiao Li
4
,
Xiao Li
1
4
Gene Editing Laboratory, Texas Heart Institute, Houston, Texas 77030, USA
|
Publication type: Journal Article
Publication date: 2021-10-01
scimago Q1
wos Q1
SJR: 12.163
CiteScore: 40.8
Impact factor: 26.3
ISSN: 10747613, 10974180
PubMed ID:
34508661
Infectious Diseases
Immunology
Immunology and Allergy
Abstract
Langerhans cells (LCs) play a pivotal role in skin homeostasis, and the heterogeneity of LCs has long been considered. In this study, we have identified two steady-state (LC1 and LC2) and two activated LC subsets in the epidermis of human skin and in LCs derived from CD34+ hemopoietic stem cells (HSC-LCs) by utilizing single-cell RNA sequencing and mass cytometry. Analysis of HSC-LCs at multiple time-points during differentiation revealed that EGR1 and Notch signaling were among the top pathways regulating the bifurcation of LC1 and LC2. LC1 were characterized as classical LCs, mainly related to innate immunity and antigen processing. LC2 were similar to monocytes or myeloid dendritic cells, involving in immune responses and leukocyte activation. LC1 remained stable under inflammatory microenvironment, whereas LC2 were prone to being activated and demonstrated elevated expression of immuno-suppressive molecules. We revealed distinct human LC subsets that require different developmental regulation and orchestrate reciprocal functions.
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Total citations:
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Citations from 2024:
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GOST
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Liu X. et al. Distinct human Langerhans cell subsets orchestrate reciprocal functions and require different developmental regulation // Immunity. 2021. Vol. 54. No. 10. p. 2305-2320.e11.
GOST all authors (up to 50)
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Zhu R., Wang S., Zhao Y., Qiu Z., Liu X., Li X., Li X. Distinct human Langerhans cell subsets orchestrate reciprocal functions and require different developmental regulation // Immunity. 2021. Vol. 54. No. 10. p. 2305-2320.e11.
Cite this
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TY - JOUR
DO - 10.1016/j.immuni.2021.08.012
UR - https://doi.org/10.1016/j.immuni.2021.08.012
TI - Distinct human Langerhans cell subsets orchestrate reciprocal functions and require different developmental regulation
T2 - Immunity
AU - Zhu, Ronghui
AU - Wang, Shangshang
AU - Zhao, Yi
AU - Qiu, Zhuoqiong
AU - Liu, Xiao
AU - Li, Xiao
AU - Li, Xiao
PY - 2021
DA - 2021/10/01
PB - Elsevier
SP - 2305-2320.e11
IS - 10
VL - 54
PMID - 34508661
SN - 1074-7613
SN - 1097-4180
ER -
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@article{2021_Liu,
author = {Ronghui Zhu and Shangshang Wang and Yi Zhao and Zhuoqiong Qiu and Xiao Liu and Xiao Li and Xiao Li},
title = {Distinct human Langerhans cell subsets orchestrate reciprocal functions and require different developmental regulation},
journal = {Immunity},
year = {2021},
volume = {54},
publisher = {Elsevier},
month = {oct},
url = {https://doi.org/10.1016/j.immuni.2021.08.012},
number = {10},
pages = {2305--2320.e11},
doi = {10.1016/j.immuni.2021.08.012}
}
Cite this
MLA
Copy
Liu, Xiaochun, et al. “Distinct human Langerhans cell subsets orchestrate reciprocal functions and require different developmental regulation.” Immunity, vol. 54, no. 10, Oct. 2021, pp. 2305-2320.e11. https://doi.org/10.1016/j.immuni.2021.08.012.