International Immunopharmacology, volume 120, pages 110376
Production of monoclonal antibodies for therapeutic purposes: A review
Waller-Pulido Alejandra
1
,
Jiménez-Pérez Miriam Irene
2
,
Gonzalez-Sanchez Fabio Antonio
1
,
Rojo-Gutierrez Rocio Patricia
3
,
Torres-Anguiano Elizabeth
4
,
Aleman-Aguilar Juan Pablo
2
,
Rebeca Garcia-Varela
1
4
Molecular Biology, Research and Diagnostic Unit, San Javier Hospital, Guadalajara, Jalisco, Mexico
|
Publication type: Journal Article
Publication date: 2023-07-01
Journal:
International Immunopharmacology
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 5.6
ISSN: 15675769, 18781705
Pharmacology
Immunology
Immunology and Allergy
Abstract
Monoclonal antibodies (mAbs) have been used in the development of immunotherapies that target a variety of diseases, such as cancer, autoimmune diseases, and even viral infections; they play a key role in immunization and are expected after vaccination. However, some conditions do not promote the development of neutralizing antibodies. Production and use of mAbs, generated in biofactories, represent vast potential as aids in immunological responses when the organism cannot produce them on their own, these convey unique specificity by recognizing and targeting specific antigen. Antibodies can be defined as heterotetrametric glycoproteins of symmetric nature, and they participate as effector proteins in humoral responses. Additionally, there are different types of mAbs (murine, chimeric, humanized, human, mAbs as Antibody-drug conjugates and bispecific mAbs) discussed in the present work. When these molecules are produced in vitro as mAbs, several common techniques, such as hybridomas or phage display are used. There are several preferred cell lines that function as biofactories, for the production of mAbs, the selection of which rely on the variation of adaptability, productivity and both phenotypic and genotypic shifts. After the cell expression systems and culture techniques are used, there are diverse specialized downstream processes to achieve desired yield and isolation as well as product quality and characterization. Novel perspectives regarding these protocols represent a potential improvement for mAbs high-scale production.
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- We do not take into account publications without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Alejandra W. et al. Production of monoclonal antibodies for therapeutic purposes: A review // International Immunopharmacology. 2023. Vol. 120. p. 110376.
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Alejandra W., Miriam Irene J., Fabio Antonio G., Patricia R. R., Elizabeth T., Juan Pablo A., Garcia-Varela R. Production of monoclonal antibodies for therapeutic purposes: A review // International Immunopharmacology. 2023. Vol. 120. p. 110376.
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TY - JOUR
DO - 10.1016/j.intimp.2023.110376
UR - https://doi.org/10.1016/j.intimp.2023.110376
TI - Production of monoclonal antibodies for therapeutic purposes: A review
T2 - International Immunopharmacology
AU - Alejandra, Waller-Pulido
AU - Miriam Irene, Jiménez-Pérez
AU - Fabio Antonio, Gonzalez-Sanchez
AU - Patricia, Rojo-Gutierrez Rocio
AU - Elizabeth, Torres-Anguiano
AU - Juan Pablo, Aleman-Aguilar
AU - Garcia-Varela, Rebeca
PY - 2023
DA - 2023/07/01 00:00:00
PB - Elsevier
SP - 110376
VL - 120
SN - 1567-5769
SN - 1878-1705
ER -
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@article{2023_Alejandra,
author = {Waller-Pulido Alejandra and Jiménez-Pérez Miriam Irene and Gonzalez-Sanchez Fabio Antonio and Rojo-Gutierrez Rocio Patricia and Torres-Anguiano Elizabeth and Aleman-Aguilar Juan Pablo and Rebeca Garcia-Varela},
title = {Production of monoclonal antibodies for therapeutic purposes: A review},
journal = {International Immunopharmacology},
year = {2023},
volume = {120},
publisher = {Elsevier},
month = {jul},
url = {https://doi.org/10.1016/j.intimp.2023.110376},
pages = {110376},
doi = {10.1016/j.intimp.2023.110376}
}