Nicotinamide N-methyltransferase (NNMT): A key enzyme in cancer metabolism and therapeutic target
Publication type: Journal Article
Publication date: 2024-12-01
scimago Q1
wos Q1
SJR: 1.239
CiteScore: 7.2
Impact factor: 4.7
ISSN: 15675769, 18781705
PubMed ID:
39312861
Abstract
Emerging research has positioned Nicotinamide N-methyltransferase (NNMT) as a key player in oncology, with its heightened expression frequently observed across diverse cancers. This increased presence is tightly linked to tumor initiation, proliferation, and metastasis. The enzymatic function of NNMT is centered on the methylation of nicotinamide (NAM), utilizing S-adenosylmethionine (SAM) as the methyl donor, which results in the generation of S-adenosyl-L-homocysteine (SAH) and methyl nicotinamide (MNAM). This metabolic process reduces the availability of NAM, necessary for Nicotinamide adenine dinucleotide (NAD
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10
Total citations:
10
Citations from 2024:
10
(100%)
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GOST
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SUN W. et al. Nicotinamide N-methyltransferase (NNMT): A key enzyme in cancer metabolism and therapeutic target // International Immunopharmacology. 2024. Vol. 142. No. Pt B. p. 113208.
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SUN W., Zhu X., Li J., Mei Y., Li W., Li J. H. Nicotinamide N-methyltransferase (NNMT): A key enzyme in cancer metabolism and therapeutic target // International Immunopharmacology. 2024. Vol. 142. No. Pt B. p. 113208.
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RIS
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TY - JOUR
DO - 10.1016/j.intimp.2024.113208
UR - https://linkinghub.elsevier.com/retrieve/pii/S1567576924017302
TI - Nicotinamide N-methyltransferase (NNMT): A key enzyme in cancer metabolism and therapeutic target
T2 - International Immunopharmacology
AU - SUN, WEI-DONG
AU - Zhu, Xiaojuan
AU - Li, Jingjing
AU - Mei, Ya-Zhong
AU - Li, Wensong
AU - Li, Jiang Hua
PY - 2024
DA - 2024/12/01
PB - Elsevier
SP - 113208
IS - Pt B
VL - 142
PMID - 39312861
SN - 1567-5769
SN - 1878-1705
ER -
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BibTex (up to 50 authors)
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@article{2024_SUN,
author = {WEI-DONG SUN and Xiaojuan Zhu and Jingjing Li and Ya-Zhong Mei and Wensong Li and Jiang Hua Li},
title = {Nicotinamide N-methyltransferase (NNMT): A key enzyme in cancer metabolism and therapeutic target},
journal = {International Immunopharmacology},
year = {2024},
volume = {142},
publisher = {Elsevier},
month = {dec},
url = {https://linkinghub.elsevier.com/retrieve/pii/S1567576924017302},
number = {Pt B},
pages = {113208},
doi = {10.1016/j.intimp.2024.113208}
}
Cite this
MLA
Copy
SUN, WEI-DONG, et al. “Nicotinamide N-methyltransferase (NNMT): A key enzyme in cancer metabolism and therapeutic target.” International Immunopharmacology, vol. 142, no. Pt B, Dec. 2024, p. 113208. https://linkinghub.elsevier.com/retrieve/pii/S1567576924017302.