A balance of interleukin-12 and -23 in cancer
Publication type: Journal Article
Publication date: 2013-11-01
scimago Q1
wos Q1
SJR: 3.895
CiteScore: 21.2
Impact factor: 13.9
ISSN: 14714906, 14714981
PubMed ID:
23954142
Immunology
Immunology and Allergy
Abstract
Interleukin (IL)-12 and IL-23 share the IL-12p40 molecule. IL-12 promotes T helper (Th)1 immunity and IL-23 promotes Th17 immunity, and it has recently become apparent that the balance between IL-12 and IL-23 is important in carcinogenesis. A series of studies demonstrated that, where tumor initiation, growth, and metastasis are concerned, IL-12 may act independently of interferon (IFN)-γ, and IL-23 independently of IL-17A. This review explores the activity of IL-23 in carcinogenesis. In the context of the tumor-inhibitory effects of IL-12, and tumor-promoting effects of IL-23, we discuss the use of anti-IL-12p/23 monoclonal antibodies (mAbs) in autoimmune inflammatory disorders and the alternative specific neutralization of IL-23.
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Metrics
98
Total citations:
98
Citations from 2024:
11
(11.22%)
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GOST
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Ngiow S. F. et al. A balance of interleukin-12 and -23 in cancer // Trends in Immunology. 2013. Vol. 34. No. 11. pp. 548-555.
GOST all authors (up to 50)
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Ngiow S. F., Teng M. W., SMYTH M. J. A balance of interleukin-12 and -23 in cancer // Trends in Immunology. 2013. Vol. 34. No. 11. pp. 548-555.
Cite this
RIS
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TY - JOUR
DO - 10.1016/j.it.2013.07.004
UR - https://doi.org/10.1016/j.it.2013.07.004
TI - A balance of interleukin-12 and -23 in cancer
T2 - Trends in Immunology
AU - Ngiow, Shin Foong
AU - Teng, Michele W.L.
AU - SMYTH, MARK J.
PY - 2013
DA - 2013/11/01
PB - Elsevier
SP - 548-555
IS - 11
VL - 34
PMID - 23954142
SN - 1471-4906
SN - 1471-4981
ER -
Cite this
BibTex (up to 50 authors)
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@article{2013_Ngiow,
author = {Shin Foong Ngiow and Michele W.L. Teng and MARK J. SMYTH},
title = {A balance of interleukin-12 and -23 in cancer},
journal = {Trends in Immunology},
year = {2013},
volume = {34},
publisher = {Elsevier},
month = {nov},
url = {https://doi.org/10.1016/j.it.2013.07.004},
number = {11},
pages = {548--555},
doi = {10.1016/j.it.2013.07.004}
}
Cite this
MLA
Copy
Ngiow, Shin Foong, et al. “A balance of interleukin-12 and -23 in cancer.” Trends in Immunology, vol. 34, no. 11, Nov. 2013, pp. 548-555. https://doi.org/10.1016/j.it.2013.07.004.