Open Access
Elamipretide Improves Mitochondrial Function in the Failing Human Heart
Kathryn Chatfield
1
,
Genevieve C Sparagna
2
,
Sarah Chau
3
,
Elisabeth K Phillips
3
,
Amrut V. Ambardekar
3
,
Zhen Qin
4
,
Max B Mitchell
3
,
Carmen C Sucharov
3
,
Shelley D. Miyamoto
3, 5
,
B. Stauffer
3, 6
1
4
Department of Surgery/Division of Cardiothoracic Surgery
6
Denver Health Medical Center
|
Publication type: Journal Article
Publication date: 2019-04-29
scimago Q1
wos Q1
SJR: 2.496
CiteScore: 12.0
Impact factor: 7.2
ISSN: 2452302X
PubMed ID:
31061916
Cardiology and Cardiovascular Medicine
Abstract
Negative alterations of mitochondria are known to occur in heart failure (HF). This study investigated the novel mitochondrial-targeted therapeutic agent elamipretide on mitochondrial and supercomplex function in failing human hearts ex vivo. Freshly explanted failing and nonfailing ventricular tissue from children and adults was treated with elamipretide. Mitochondrial oxygen flux, complex (C) I and CIV activities, and in-gel activity of supercomplex assembly were measured. Mitochondrial function was impaired in the failing human heart, and mitochondrial oxygen flux, CI and CIV activities, and supercomplex-associated CIV activity significantly improved in response to elamipretide treatment. Elamipretide significantly improved failing human mitochondrial function.
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Total citations:
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Citations from 2024:
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(36.85%)
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GOST
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Chatfield K. et al. Elamipretide Improves Mitochondrial Function in the Failing Human Heart // JACC: Basic to Translational Science. 2019. Vol. 4. No. 2. pp. 147-157.
GOST all authors (up to 50)
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Chatfield K., Sparagna G. C., Chau S., Phillips E. K., Ambardekar A. V., Qin Z., Mitchell M. B., Sucharov C. C., Miyamoto S. D., Stauffer B. Elamipretide Improves Mitochondrial Function in the Failing Human Heart // JACC: Basic to Translational Science. 2019. Vol. 4. No. 2. pp. 147-157.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.jacbts.2018.12.005
UR - https://doi.org/10.1016/j.jacbts.2018.12.005
TI - Elamipretide Improves Mitochondrial Function in the Failing Human Heart
T2 - JACC: Basic to Translational Science
AU - Chatfield, Kathryn
AU - Sparagna, Genevieve C
AU - Chau, Sarah
AU - Phillips, Elisabeth K
AU - Ambardekar, Amrut V.
AU - Qin, Zhen
AU - Mitchell, Max B
AU - Sucharov, Carmen C
AU - Miyamoto, Shelley D.
AU - Stauffer, B.
PY - 2019
DA - 2019/04/29
PB - Elsevier
SP - 147-157
IS - 2
VL - 4
PMID - 31061916
SN - 2452-302X
ER -
Cite this
BibTex (up to 50 authors)
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@article{2019_Chatfield,
author = {Kathryn Chatfield and Genevieve C Sparagna and Sarah Chau and Elisabeth K Phillips and Amrut V. Ambardekar and Zhen Qin and Max B Mitchell and Carmen C Sucharov and Shelley D. Miyamoto and B. Stauffer},
title = {Elamipretide Improves Mitochondrial Function in the Failing Human Heart},
journal = {JACC: Basic to Translational Science},
year = {2019},
volume = {4},
publisher = {Elsevier},
month = {apr},
url = {https://doi.org/10.1016/j.jacbts.2018.12.005},
number = {2},
pages = {147--157},
doi = {10.1016/j.jacbts.2018.12.005}
}
Cite this
MLA
Copy
Chatfield, Kathryn, et al. “Elamipretide Improves Mitochondrial Function in the Failing Human Heart.” JACC: Basic to Translational Science, vol. 4, no. 2, Apr. 2019, pp. 147-157. https://doi.org/10.1016/j.jacbts.2018.12.005.