Journal of Affective Disorders, volume 369, pages 118-124

Cognitive impairment of medicated patients with remitted depression and low anticholinergic activity

Naoto Yoshinari ¹

Hitoshi Maeshima ²

Kentaro Shimizu ¹

Hajime Baba ¹

Juntendo University Mood Disorder Project (JUMP), Department of Psychiatry, Juntendo Koshigaya Hospital, 560 Fukuroyama, Koshigaya City, Saitama 343-0046, Japan; Department of Psychiatry, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan. |

Publication type: Journal Article

Publication date: 2025-01-01

Elsevier

Journal: Journal of Affective Disorders

scimago Q1

SJR: 2.082

CiteScore: 10.9

Impact factor: 4.9

ISSN: 01650327, 15732517

DOI: 10.1016/j.jad.2024.09.152

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Abstract

A recent meta-analysis has found that patients who have achieved remission of major depressive disorder (MDD) show cognitive dysfunction. Moreover, anticholinergic activity levels are associated with cognitive dysfunction, although the extent of these effects is unclear. Therefore, we measured serum anticholinergic activity (SAA) in blood samples of patients with remitted MDD and examined its relationship with cognitive function.

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Publisher

Elsevier

Journal

Journal of Affective Disorders

scimago Q1

SJR

2.082

CiteScore

10.9

Impact factor

4.9

ISSN

01650327 (Print)

15732517 (Electronic)