Leucas cephalotes regulates carbohydrate and lipid metabolism and improves antioxidant status in IDDM and NIDDM rats
Publication type: Journal Article
Publication date: 2010-01-01
scimago Q1
wos Q1
SJR: 1.142
CiteScore: 10.4
Impact factor: 5.4
ISSN: 03788741, 18727573
PubMed ID:
19799987
Drug Discovery
Pharmacology
Abstract
Leucas cephalotes (Roth.) Spreng. (Laminaceae) is an ayurvedic traditional medicinal plant used in India, Nepal and Pakistan to treat several ailments including diabetes.The aim of the present study is to investigate the antidiabetic, antihyperlipaemic and antioxidant activities of Leucas cephalotes for its purported use in diabetes.The ethanol extract of leaves of Leucas cephalotes was administered (150, 300 and 450 mg kg(-1)bw) to diabetes induced (IDDM and NIDDM) rats and carbohydrate, lipid, antioxidant, urea and creatinine profiles were assessed.All the three doses of extract decreased plasma glucose and lipid profiles and, improved the antioxidant status of both types of diabetic rats. The extract administration improved hepatic glycogen content and hexokinase activity, decreased glucose-6-phosphatase activity, blood urea, creatinine contents and decreased lipid peroxidation in diabetic rats. Of the three doses used, 450 mg kg(-1)bw dose was found to be more potent in its effects comparable to those of glibenclamide and metformin.Leucas cephalotes regulates both carbohydrate and lipid metabolism and, improves body antioxidant defense systems in both types of diabetes.
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Bavarva J. H., Narasimhacharya A. V. R. L. Leucas cephalotes regulates carbohydrate and lipid metabolism and improves antioxidant status in IDDM and NIDDM rats // Journal of Ethnopharmacology. 2010. Vol. 127. No. 1. pp. 98-102.
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Bavarva J. H., Narasimhacharya A. V. R. L. Leucas cephalotes regulates carbohydrate and lipid metabolism and improves antioxidant status in IDDM and NIDDM rats // Journal of Ethnopharmacology. 2010. Vol. 127. No. 1. pp. 98-102.
Cite this
RIS
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TY - JOUR
DO - 10.1016/j.jep.2009.09.042
UR - https://doi.org/10.1016/j.jep.2009.09.042
TI - Leucas cephalotes regulates carbohydrate and lipid metabolism and improves antioxidant status in IDDM and NIDDM rats
T2 - Journal of Ethnopharmacology
AU - Bavarva, Jasmin H.
AU - Narasimhacharya, A V R L
PY - 2010
DA - 2010/01/01
PB - Elsevier
SP - 98-102
IS - 1
VL - 127
PMID - 19799987
SN - 0378-8741
SN - 1872-7573
ER -
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BibTex (up to 50 authors)
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@article{2010_Bavarva,
author = {Jasmin H. Bavarva and A V R L Narasimhacharya},
title = {Leucas cephalotes regulates carbohydrate and lipid metabolism and improves antioxidant status in IDDM and NIDDM rats},
journal = {Journal of Ethnopharmacology},
year = {2010},
volume = {127},
publisher = {Elsevier},
month = {jan},
url = {https://doi.org/10.1016/j.jep.2009.09.042},
number = {1},
pages = {98--102},
doi = {10.1016/j.jep.2009.09.042}
}
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MLA
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Bavarva, Jasmin H., and A V R L Narasimhacharya. “Leucas cephalotes regulates carbohydrate and lipid metabolism and improves antioxidant status in IDDM and NIDDM rats.” Journal of Ethnopharmacology, vol. 127, no. 1, Jan. 2010, pp. 98-102. https://doi.org/10.1016/j.jep.2009.09.042.