Journal of Ethnopharmacology

, volume 128 , issue 3 , pages 629-633

Hypoglycemic effects of Cecropia pachystachya in normal and alloxan-induced diabetic rats

Danielle M O Aragão ¹

Lyvia Guarize ¹

Juliana Lanini ²

Juliana Conceição Noschang da Costa ¹

Raul M G Garcia ²

Elita Scio ¹

Hide authors affiliations Show authors affiliations: 2 affiliations

Departamento de Bioquímica – ICB – Universidade Federal de Juiz de Fora, Campus Universitário, Martelos, CEP 36036 900, Juiz de Fora, MG, Brazil |

Departamento de Biologia – ICB – Universidade Federal de Juiz de Fora, Campus Universitário, Martelos, CEP 36036 900, Juiz de Fora, MG, Brazil |

Publication type: Journal Article

Publication date: 2010-04-01

Elsevier

Journal of Ethnopharmacology

scimago Q1

wos Q1

SJR: 1.142

CiteScore: 10.4

Impact factor: 5.4

ISSN: 03788741, 18727573

DOI: 10.1016/j.jep.2010.01.008

Copy DOI

PubMed ID: 20064597

Drug Discovery

Pharmacology

Abstract

Leaves of Cecropia pachystachya are described in the folk medicine as possessing antitusive, expectorant, antiasthmatic and hypoglycemic effects.To investigate the hypoglycemic and antioxidant effects of methanolic extract from the leaves of Cecropia pachystachya. The total amount of phenolic and flavonoids compounds was determined and the qualitative composition of the extract was analyzed.The hypoglycemic effect of the extract was tested in normal, glucose loading and alloxan-induced diabetic rats. The antioxidant activity was assessed by DPPH free radical scavenging and reduction power assays. The total amount of phenolic and flavonoids compounds was determined by Folin-Denis and AlCl(3) reagent method, respectively. The qualitative composition of the extract was analyzed using a HPLC-DAD system.The glucose tolerance test showed that in diabetic rats, the extract caused a significant hypoglycemic effect with a blood glucose reduction of 68% after 12h. The administration of the extract in alloxan-induced diabetic rats also produced a significant reduction in the blood glucose levels at all points being more pronounced at 90min (reduction of 60%). After 120min, no significant difference was observed between the blood levels of the rats treated with the extract and those treated with the standard drugs (metformin and glibenclamide). The extract also presented relevant antioxidant activity with IC50=3.1microg/ml (DPPH assay) and EC50=10.8microg/ml (reduction power). Results were compared with the reference antioxidants quercetin, rutin, and ascorbic acid. The content of flavonoids was 83mg/g plant and that of phenolics was 326mg/g plant. Chlorogenic acid and the C-glycosylated flavones, orientin and isoorientin, were identified in the extract.In conclusion, the findings showed that the folk medicinal plant Cecropia pachystachya possesses hypoglycemic and antioxidant effects which confirmed the traditional use of the plant in the treatment of diabetes. Chlorogenic acid and the C-glycosylated flavonoids may explain these activities.

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GOST Copy

Aragão D. M. O. et al. Hypoglycemic effects of Cecropia pachystachya in normal and alloxan-induced diabetic rats // Journal of Ethnopharmacology. 2010. Vol. 128. No. 3. pp. 629-633.

GOST all authors (up to 50) Copy

Aragão D. M. O., Guarize L., Lanini J., da Costa J. C. N., Garcia R. M. G., Scio E. Hypoglycemic effects of Cecropia pachystachya in normal and alloxan-induced diabetic rats // Journal of Ethnopharmacology. 2010. Vol. 128. No. 3. pp. 629-633.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1016/j.jep.2010.01.008

UR - https://doi.org/10.1016/j.jep.2010.01.008

TI - Hypoglycemic effects of Cecropia pachystachya in normal and alloxan-induced diabetic rats

T2 - Journal of Ethnopharmacology

AU - Aragão, Danielle M O

AU - Guarize, Lyvia

AU - Lanini, Juliana

AU - da Costa, Juliana Conceição Noschang

AU - Garcia, Raul M G

AU - Scio, Elita

PY - 2010

DA - 2010/04/01

PB - Elsevier

SP - 629-633

IS - 3

VL - 128

PMID - 20064597

SN - 0378-8741

SN - 1872-7573

ER -

BibTex |

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BibTex (up to 50 authors) Copy

@article{2010_Aragão,

author = {Danielle M O Aragão and Lyvia Guarize and Juliana Lanini and Juliana Conceição Noschang da Costa and Raul M G Garcia and Elita Scio},

title = {Hypoglycemic effects of Cecropia pachystachya in normal and alloxan-induced diabetic rats},

journal = {Journal of Ethnopharmacology},

year = {2010},

volume = {128},

publisher = {Elsevier},

month = {apr},

url = {https://doi.org/10.1016/j.jep.2010.01.008},

number = {3},

pages = {629--633},

doi = {10.1016/j.jep.2010.01.008}

}

MLA

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MLA Copy

Aragão, Danielle M. O., et al. “Hypoglycemic effects of Cecropia pachystachya in normal and alloxan-induced diabetic rats.” Journal of Ethnopharmacology, vol. 128, no. 3, Apr. 2010, pp. 629-633. https://doi.org/10.1016/j.jep.2010.01.008.

Publisher

Elsevier

Journal

Journal of Ethnopharmacology

scimago Q1

wos Q1

SJR

1.142

CiteScore

10.4

Impact factor

5.4

ISSN

03788741 (Print)

18727573 (Electronic)