Open Access
Open access
Elsevier
Journal of Functional Foods
,  volume 110 ,  pages 105835

Camel whey protein improves diabetic liver injury by targeting ACMSD and promoting de novo NAD+ synthesis

Zhihua Dou 1
, 
Huaibin Yao 1
, 
Yutong Xie 1
, 
Ying Liu 1, 2
, 
Ge Yang 3
, 
Jie Yang 1, 2
1
 
2
 
Xinjiang Camel Industry Engineering Technology Research Center, Urumqi, Xinjiang 830046, China | 
3
 
Publication type: Journal Article
Publication date: 2023-11-01
Elsevier
scimago Q1
wos Q2
SJR: 0.837
CiteScore: 6.9
Impact factor: 4.0
ISSN: 17564646, 22149414
Medicine (miscellaneous)
Food Science
Nutrition and Dietetics
Abstract
Diabetic liver injury is a complication of diabetes without any specific medicine approved for its effective treatment or prevention. In this research, the effect of camel whey protein (CWP) on diabetic liver injury in T2DM rats (T2DM induced by a high-fat diet) and streptozotocin along with its possible mechanism were investigated by means of transcriptome and proteomics. The results demonstrated that CWP lowered fasting blood glucose and improved abnormal blood lipid profiles in T2DM rats. CWP reduced lipid accumulation, diminished oxidative stress, and effectively improved the pathological changes in the liver of T2DM rats. Further experiments indicated that CWP intake had adjusted mitochondrial dysfunction in the livers of T2DM rats and L-O2 cells induced by high glucose (HG)/palmitic acid (PA) by inhibiting α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase (ACMSD) expression. In conclusion, CWP can ameliorate diabetic liver injury in T2DM rats by inhibiting the expression of ACMSD, promote de novo NAD+ synthesis and enhance mitochondrial function.
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GOST |
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GOST Copy
Dou Z. et al. Camel whey protein improves diabetic liver injury by targeting ACMSD and promoting de novo NAD+ synthesis // Journal of Functional Foods. 2023. Vol. 110. p. 105835.
GOST all authors (up to 50) Copy
Dou Z., Yao H., Xie Y., Liu Y., Yang G., Yang J. Camel whey protein improves diabetic liver injury by targeting ACMSD and promoting de novo NAD+ synthesis // Journal of Functional Foods. 2023. Vol. 110. p. 105835.
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RIS Copy
TY - JOUR
DO - 10.1016/j.jff.2023.105835
UR - https://doi.org/10.1016/j.jff.2023.105835
TI - Camel whey protein improves diabetic liver injury by targeting ACMSD and promoting de novo NAD+ synthesis
T2 - Journal of Functional Foods
AU - Dou, Zhihua
AU - Yao, Huaibin
AU - Xie, Yutong
AU - Liu, Ying
AU - Yang, Ge
AU - Yang, Jie
PY - 2023
DA - 2023/11/01
PB - Elsevier
SP - 105835
VL - 110
SN - 1756-4646
SN - 2214-9414
ER -
BibTex
Cite this
BibTex (up to 50 authors) Copy
@article{2023_Dou,
author = {Zhihua Dou and Huaibin Yao and Yutong Xie and Ying Liu and Ge Yang and Jie Yang},
title = {Camel whey protein improves diabetic liver injury by targeting ACMSD and promoting de novo NAD+ synthesis},
journal = {Journal of Functional Foods},
year = {2023},
volume = {110},
publisher = {Elsevier},
month = {nov},
url = {https://doi.org/10.1016/j.jff.2023.105835},
pages = {105835},
doi = {10.1016/j.jff.2023.105835}
}