Open Access

Journal of Microbiology, Immunology and Infection

, volume 58 , issue 2 , pages 198-208

Dengue Virus Non-structural Protein 1 Binding to Thrombin as a Dengue Severity Marker: Comprehensive Patient Analysis in South Taiwan

Josephine Diony Nanda ^{1, 2, 3}

Trai-Ming Yeh ^{4, 5, 6}

Rahmat Dani Satria ⁷

Ming-Kai Jhan ^{2, 8}

Yung-Ting Wang ^{2, 8}

Ya-Lan Lin ^{6, 9}

Yalan Lin ¹⁰

Herdiantri Sufriyana ^{11, 12, 13}

Emily Su ^{12, 14, 15, 16}

Chiou-Fen Lin ^{2, 6, 17, 18, 19}

Tzong-Shiann Ho ^{6, 9, 20, 21}

Hide authors affiliations Show authors affiliations: 21 affiliations

Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 110, Taiwan; Departement of Parasitology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, 55281, Indonesia.

Taipei Medical University

Gadjah Mada University

Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 110, Taiwan |

Departement of Parasitology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, 55281, Indonesia |

⁴

Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Center of Infectious Disease and Signaling Research, National Cheng Kung University, Tainan, Taiwan. |

⁵

Department of Medical Laboratory Science and BioTechnology, College of Medicine, National Cheng Kung University, Tainan, Taiwan |

⁶

Center of Infectious Disease and Signaling Research, National Cheng Kung University, Tainan, Taiwan |

⁷

Department of Clinical Pathology and Laboratory Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, 55281, Indonesia; Clinical Laboratory Installation, Dr. Sardjito Central General Hospital, Yogyakarta, 55281, Indonesia. |

⁸

Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 110, Taiwan. |

⁹

Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, 704, Taiwan |

¹⁰

¹¹

Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan; Department of Medical Physiology, Faculty of Medicine, Universitas Nahdlatul Ulama Surabaya, Surabaya, Indonesia.

Taipei Medical University

Nahdlatul Ulama University of Surabaya

¹²

Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan |

¹³

Department of Medical Physiology, Faculty of Medicine, Universitas Nahdlatul Ulama Surabaya, Surabaya, Indonesia |

¹⁴

Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan; Clinical Big Data Research Center, Taipei Medical University Hospital, Taipei, Taiwan; Research Center for Artificial Intelligence in Medicine, Taipei Medical University, Taipei, Taiwan. |

¹⁵

Clinical Big Data Research Center, Taipei Medical University Hospital, Taipei, Taiwan |

¹⁶

Research Center for Artificial Intelligence in Medicine, Taipei Medical University, Taipei, Taiwan |

¹⁷

Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 110, Taiwan; Center of Infectious Disease and Signaling Research, National Cheng Kung University, Tainan, Taiwan; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, 110, Taiwan; Core Laboratory of Immune Monitoring, Office of Research & Development, Taipei Medical University, Taipei, 110, Taiwan. Electronic address: cflin2014@tmu.edu.tw.

Taipei Medical University

National Cheng Kung University

¹⁸

Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, 110, Taiwan |

¹⁹

Core Laboratory of Immune Monitoring, Office of Research & Development, Taipei Medical University, Taipei, 110, Taiwan |

²⁰

Center of Infectious Disease and Signaling Research, National Cheng Kung University, Tainan, Taiwan; Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, 704, Taiwan; Department of Pediatrics, National Cheng Kung University Hospital Dou-Liou Branch, College of Medicine, National Cheng Kung University, Yunlin 640, Taiwan. Electronic address: tsho@mail.ncku.edu.tw. |

²¹

Department of Pediatrics, National Cheng Kung University Hospital Dou-Liou Branch, College of Medicine, National Cheng Kung University, Yunlin 640, Taiwan |

Publication type: Journal Article

Publication date: 2025-04-01

Elsevier

Journal of Microbiology, Immunology and Infection

scimago Q1

wos Q2

SJR: 1.009

CiteScore: 10.1

Impact factor: 3.7

ISSN: 16841182, 19959133

DOI: 10.1016/j.jmii.2024.12.004

Copy DOI

PubMed ID: 39730269

Abstract

BackgroundPreviously we identified a complex of non-structural protein (NS) 1 – Thrombin (NST) in dengue infected patients. Here, we investigated how the concentration of NS1 and NST differ in various dengue severity levels as well as their demographic and clinical features. Several comorbid (hypertension, diabetes, and chronic renal failure) often found in dengue patients were also measured and analyzed.

Found

Top-30

Journals

	1
Frontiers in Medicine	Frontiers in Medicine, 1, 100% Frontiers in Medicine 1 publication, 100%
	1

Publishers

	1
Frontiers Media S.A.	Frontiers Media S.A., 1, 100% Frontiers Media S.A. 1 publication, 100%
	1

We do not take into account publications without a DOI.
Statistics recalculated weekly.

Are you a researcher?

Create a profile to get free access to personal recommendations for colleagues and new articles.

Metrics

Cite this

GOST |

Cite this

GOST Copy

Nanda J. D. et al. Dengue Virus Non-structural Protein 1 Binding to Thrombin as a Dengue Severity Marker: Comprehensive Patient Analysis in South Taiwan // Journal of Microbiology, Immunology and Infection. 2025. Vol. 58. No. 2. pp. 198-208.

GOST all authors (up to 50) Copy

Nanda J. D., Yeh T., Satria R. D., Jhan M., Wang Y., Lin Y., Lin Y., Sufriyana H., Su E., Lin C., Ho T. Dengue Virus Non-structural Protein 1 Binding to Thrombin as a Dengue Severity Marker: Comprehensive Patient Analysis in South Taiwan // Journal of Microbiology, Immunology and Infection. 2025. Vol. 58. No. 2. pp. 198-208.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1016/j.jmii.2024.12.004

UR - https://linkinghub.elsevier.com/retrieve/pii/S1684118224002305

TI - Dengue Virus Non-structural Protein 1 Binding to Thrombin as a Dengue Severity Marker: Comprehensive Patient Analysis in South Taiwan

T2 - Journal of Microbiology, Immunology and Infection

AU - Nanda, Josephine Diony

AU - Yeh, Trai-Ming

AU - Satria, Rahmat Dani

AU - Jhan, Ming-Kai

AU - Wang, Yung-Ting

AU - Lin, Ya-Lan

AU - Lin, Yalan

AU - Sufriyana, Herdiantri

AU - Su, Emily

AU - Lin, Chiou-Fen

AU - Ho, Tzong-Shiann

PY - 2025

DA - 2025/04/01

PB - Elsevier

SP - 198-208

IS - 2

VL - 58

PMID - 39730269

SN - 1684-1182

SN - 1995-9133

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2025_Nanda,

author = {Josephine Diony Nanda and Trai-Ming Yeh and Rahmat Dani Satria and Ming-Kai Jhan and Yung-Ting Wang and Ya-Lan Lin and Yalan Lin and Herdiantri Sufriyana and Emily Su and Chiou-Fen Lin and Tzong-Shiann Ho},

title = {Dengue Virus Non-structural Protein 1 Binding to Thrombin as a Dengue Severity Marker: Comprehensive Patient Analysis in South Taiwan},

journal = {Journal of Microbiology, Immunology and Infection},

year = {2025},

volume = {58},

publisher = {Elsevier},

month = {apr},

url = {https://linkinghub.elsevier.com/retrieve/pii/S1684118224002305},

number = {2},

pages = {198--208},

doi = {10.1016/j.jmii.2024.12.004}

}

MLA

Cite this

MLA Copy

Nanda, Josephine Diony, et al. “Dengue Virus Non-structural Protein 1 Binding to Thrombin as a Dengue Severity Marker: Comprehensive Patient Analysis in South Taiwan.” Journal of Microbiology, Immunology and Infection, vol. 58, no. 2, Apr. 2025, pp. 198-208. https://linkinghub.elsevier.com/retrieve/pii/S1684118224002305.

Publisher

Elsevier

Journal

Journal of Microbiology, Immunology and Infection

scimago Q1

wos Q2

SJR

1.009

CiteScore

10.1

Impact factor

3.7

ISSN

16841182 (Print)

19959133 (Electronic)

Profiles