Open Access
Open access
Elsevier
Journal of Orthopaedic Translation
,  volume 51 ,  pages 163-175

Inhibition of ERK1/2 mediated activation of Drp1 alleviates intervertebral disc degeneration via suppressing pyroptosis and apoptosis in nucleus pulposus cells

Shenkai Su 1, 2, 3
, 
Xuanzhang Wu 1, 2, 3
, 
Bin Li 4
, 
Fengyu Zhang 2
, 
Kaiying Zhang 2
, 
Hui Wang 3, 5
, 
Lin Yan 1, 2, 3
, 
Jiaoxiang Chen 1, 2, 3
1
 
2
 
3
 
Zhejiang Provincial Key Laboratory of Orthopaedics, Wenzhou, Zhejiang Province, China | 
4
 
Department of Orthopaedics, Yuhuan People’s Hospital, Taizhou, Zhejiang Province, China | 
5
 
Publication type: Journal Article
Publication date: 2025-03-13
Elsevier
scimago Q1
wos Q1
SJR: 1.641
CiteScore: 13.5
Impact factor: 7.8
ISSN: 2214031X
Abstract
ObjectiveDynamin-related protein 1 (Drp1) plays a crucial role in various inflammatory and degenerative diseases, yet its involvement in intervertebral disc degeneration (IVDD) remains poorly understood. This study aims to elucidate the mechanism by which Drp1 contributes to IVDD and to identify the efficacy of the Drp1 inhibitor Mdivi-1 on IVDD.
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Su S. et al. Inhibition of ERK1/2 mediated activation of Drp1 alleviates intervertebral disc degeneration via suppressing pyroptosis and apoptosis in nucleus pulposus cells // Journal of Orthopaedic Translation. 2025. Vol. 51. pp. 163-175.
GOST all authors (up to 50) Copy
Su S., Wu X., Li B., Zhang F., Zhang K., Wang H., Lin Yan, Chen J. Inhibition of ERK1/2 mediated activation of Drp1 alleviates intervertebral disc degeneration via suppressing pyroptosis and apoptosis in nucleus pulposus cells // Journal of Orthopaedic Translation. 2025. Vol. 51. pp. 163-175.
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TY - JOUR
DO - 10.1016/j.jot.2025.01.013
UR - https://linkinghub.elsevier.com/retrieve/pii/S2214031X25000142
TI - Inhibition of ERK1/2 mediated activation of Drp1 alleviates intervertebral disc degeneration via suppressing pyroptosis and apoptosis in nucleus pulposus cells
T2 - Journal of Orthopaedic Translation
AU - Su, Shenkai
AU - Wu, Xuanzhang
AU - Li, Bin
AU - Zhang, Fengyu
AU - Zhang, Kaiying
AU - Wang, Hui
AU - Lin Yan
AU - Chen, Jiaoxiang
PY - 2025
DA - 2025/03/13
PB - Elsevier
SP - 163-175
VL - 51
SN - 2214-031X
ER -
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@article{2025_Su,
author = {Shenkai Su and Xuanzhang Wu and Bin Li and Fengyu Zhang and Kaiying Zhang and Hui Wang and Lin Yan and Jiaoxiang Chen},
title = {Inhibition of ERK1/2 mediated activation of Drp1 alleviates intervertebral disc degeneration via suppressing pyroptosis and apoptosis in nucleus pulposus cells},
journal = {Journal of Orthopaedic Translation},
year = {2025},
volume = {51},
publisher = {Elsevier},
month = {mar},
url = {https://linkinghub.elsevier.com/retrieve/pii/S2214031X25000142},
pages = {163--175},
doi = {10.1016/j.jot.2025.01.013}
}