Trace level detection and quantitation of ethyl diazoacetate by reversed-phase high performance liquid chromatography and UV detection
1
Analytical Sciences Research & Development, Eli Lilly & Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
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Publication type: Journal Article
Publication date: 2006-06-01
scimago Q2
wos Q2
SJR: 0.628
CiteScore: 6.4
Impact factor: 3.1
ISSN: 07317085, 1873264X
PubMed ID:
16495031
Drug Discovery
Spectroscopy
Pharmaceutical Science
Clinical Biochemistry
Analytical Chemistry
Abstract
A method using reversed-phase high performance liquid chromatography (HPLC) with UV detection has been developed and validated for the trace level (ng/mL) detection and quantitation of ethyl diazoacetate (EDA), a toxic impurity, in sample matrix. Method development included the evaluation of several analytical techniques including LC-MS and GC-MS, which in this case, proved to be unacceptable means of analysis. The chromatographic separation employed in this method utilizes a mobile phase system of acetonitrile and water with analysis carried out using UV detection at 250 nm. The final method showed excellent linearity, accuracy, repeatability, specificity and recovery when evaluated at the quantitation limit (QL) of 6 ng/mL.
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GOST
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Axe B. P. Trace level detection and quantitation of ethyl diazoacetate by reversed-phase high performance liquid chromatography and UV detection // Journal of Pharmaceutical and Biomedical Analysis. 2006. Vol. 41. No. 3. pp. 804-810.
GOST all authors (up to 50)
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Axe B. P. Trace level detection and quantitation of ethyl diazoacetate by reversed-phase high performance liquid chromatography and UV detection // Journal of Pharmaceutical and Biomedical Analysis. 2006. Vol. 41. No. 3. pp. 804-810.
Cite this
RIS
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TY - JOUR
DO - 10.1016/j.jpba.2006.01.031
UR - https://doi.org/10.1016/j.jpba.2006.01.031
TI - Trace level detection and quantitation of ethyl diazoacetate by reversed-phase high performance liquid chromatography and UV detection
T2 - Journal of Pharmaceutical and Biomedical Analysis
AU - Axe, Brian P
PY - 2006
DA - 2006/06/01
PB - Elsevier
SP - 804-810
IS - 3
VL - 41
PMID - 16495031
SN - 0731-7085
SN - 1873-264X
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2006_Axe,
author = {Brian P Axe},
title = {Trace level detection and quantitation of ethyl diazoacetate by reversed-phase high performance liquid chromatography and UV detection},
journal = {Journal of Pharmaceutical and Biomedical Analysis},
year = {2006},
volume = {41},
publisher = {Elsevier},
month = {jun},
url = {https://doi.org/10.1016/j.jpba.2006.01.031},
number = {3},
pages = {804--810},
doi = {10.1016/j.jpba.2006.01.031}
}
Cite this
MLA
Copy
Axe, Brian P.. “Trace level detection and quantitation of ethyl diazoacetate by reversed-phase high performance liquid chromatography and UV detection.” Journal of Pharmaceutical and Biomedical Analysis, vol. 41, no. 3, Jun. 2006, pp. 804-810. https://doi.org/10.1016/j.jpba.2006.01.031.