Journal of Thermal Biology, volume 98, pages 102906
Pharmacological torpor prolongs rat survival in lethal normobaric hypoxia
3
Russian Foundation for Advanced Research, Russia.
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Publication type: Journal Article
Publication date: 2021-05-01
Journal:
Journal of Thermal Biology
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 2.7
ISSN: 03064565, 18790992
Biochemistry
General Agricultural and Biological Sciences
Developmental Biology
Physiology
Abstract
Resistance to hypoxia is one of the most prominent features of natural hibernation and is expected to be present in the pharmacological torpor (PT) that simulates hibernation. We studied resistance to lethal hypoxia (3.5% oxygen content) in rats under PT. To initiate PT, we used the previously developed pharmacological composition (PC) which, after a single intravenous injection, can induce a daily decrease in Tb by 7 °C-8 °C at the environmental temperature of 22 °C-23 °C. Half-survival (median) time of rats in lethal hypoxia was found to increase from 5 ± 0.8 min in anesthetized control rats to 150 ± 12 min in rats injected with PC, which is a 30-fold increase. Behavioral tests after PT and hypoxia, including the traveling distance, the number of rearing and grooming episodes, revealed that animal responses are significantly restored within a week. It is assumed that the discovered unprecedented resistance of artificially torpid rats to lethal hypoxia may open up broad prospects for the therapeutic use of PT for preconditioning to various damaging factors, treatment of diseases, and extend the so-called "golden hour" for lifesaving interventions.
Citations by journals
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1
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Journal of Pharmaceutical Sciences
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Journal of Pharmaceutical Sciences
1 publication, 100%
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1
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Citations by publishers
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1
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Elsevier
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Elsevier
1 publication, 100%
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Zakharova N. M. et al. Pharmacological torpor prolongs rat survival in lethal normobaric hypoxia // Journal of Thermal Biology. 2021. Vol. 98. p. 102906.
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Zakharova N. M., Tarahovsky Y. S., Komelina N. P., Khrenov M. O., Kovtun A. L. Pharmacological torpor prolongs rat survival in lethal normobaric hypoxia // Journal of Thermal Biology. 2021. Vol. 98. p. 102906.
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TY - JOUR
DO - 10.1016/j.jtherbio.2021.102906
UR - https://doi.org/10.1016%2Fj.jtherbio.2021.102906
TI - Pharmacological torpor prolongs rat survival in lethal normobaric hypoxia
T2 - Journal of Thermal Biology
AU - Zakharova, Nadezhda M
AU - Tarahovsky, Yury S.
AU - Komelina, Natalia P
AU - Khrenov, Maxim O
AU - Kovtun, Anatoly L
PY - 2021
DA - 2021/05/01 00:00:00
PB - Elsevier
SP - 102906
VL - 98
SN - 0306-4565
SN - 1879-0992
ER -
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@article{2021_Zakharova,
author = {Nadezhda M Zakharova and Yury S. Tarahovsky and Natalia P Komelina and Maxim O Khrenov and Anatoly L Kovtun},
title = {Pharmacological torpor prolongs rat survival in lethal normobaric hypoxia},
journal = {Journal of Thermal Biology},
year = {2021},
volume = {98},
publisher = {Elsevier},
month = {may},
url = {https://doi.org/10.1016%2Fj.jtherbio.2021.102906},
pages = {102906},
doi = {10.1016/j.jtherbio.2021.102906}
}
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