Open Access
Sennidin stimulates glucose incorporation in rat adipocytes
1
National Agricultural Research Center for Western Region, 1-3-1 Senyu-cho, Zentsuji, Kagawa 765-8508, Japan.
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Publication type: Journal Article
Publication date: 2006-08-01
scimago Q1
wos Q1
SJR: 1.315
CiteScore: 10.9
Impact factor: 5.1
ISSN: 00243205, 18790631
PubMed ID:
16603199
General Biochemistry, Genetics and Molecular Biology
General Medicine
General Pharmacology, Toxicology and Pharmaceutics
Abstract
A novel small molecule compound which exerts insulin mimetic is desirable. Dozens of natural products that have quinone, naphthoquinone, or anthraquinone structure, were tested by a glucose incorporation assay. We found that sennidin A, anthraquinone derivative, stimulated glucose incorporation to near level of maximal insulin-stimulated and sennidin B, a stereoisomer of sennidin A, also stimulated, but the activity of sennidin B was lower than sennidin A. Sennidin A-stimulated glucose incorporation was completely inhibited by wortmannin. Sennidin A did not induce tyrosine phosphorylation of insulin receptor (IR) and insulin receptor substrate-1 (IRS-1), but induced phosphorylation of Akt and glucose transporter 4 (GLUT4) translocation. Our results suggest that in rat adipocytes, sennidin A stimulates glucose incorporation in the phosphatidylinositol 3-kinase (PI3K)- and Akt-dependent, but in the IR/IRS1-independent manner.
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Total citations:
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Citations from 2024:
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GOST
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Abe D., Saito T., SEKIYA K. Sennidin stimulates glucose incorporation in rat adipocytes // Life Sciences. 2006. Vol. 79. No. 11. pp. 1027-1033.
GOST all authors (up to 50)
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Abe D., Saito T., SEKIYA K. Sennidin stimulates glucose incorporation in rat adipocytes // Life Sciences. 2006. Vol. 79. No. 11. pp. 1027-1033.
Cite this
RIS
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TY - JOUR
DO - 10.1016/j.lfs.2006.03.007
UR - https://doi.org/10.1016/j.lfs.2006.03.007
TI - Sennidin stimulates glucose incorporation in rat adipocytes
T2 - Life Sciences
AU - Abe, Daigo
AU - Saito, Takeshi
AU - SEKIYA, Keizo
PY - 2006
DA - 2006/08/01
PB - Elsevier
SP - 1027-1033
IS - 11
VL - 79
PMID - 16603199
SN - 0024-3205
SN - 1879-0631
ER -
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BibTex (up to 50 authors)
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@article{2006_Abe,
author = {Daigo Abe and Takeshi Saito and Keizo SEKIYA},
title = {Sennidin stimulates glucose incorporation in rat adipocytes},
journal = {Life Sciences},
year = {2006},
volume = {79},
publisher = {Elsevier},
month = {aug},
url = {https://doi.org/10.1016/j.lfs.2006.03.007},
number = {11},
pages = {1027--1033},
doi = {10.1016/j.lfs.2006.03.007}
}
Cite this
MLA
Copy
Abe, Daigo, et al. “Sennidin stimulates glucose incorporation in rat adipocytes.” Life Sciences, vol. 79, no. 11, Aug. 2006, pp. 1027-1033. https://doi.org/10.1016/j.lfs.2006.03.007.