Open Access
Life Sciences, volume 219, pages 190-198
A pharmacological composition for induction of a reversible torpor-like state and hypothermia in rats
Tarahovsky Yury S
2
,
Fadeeva Irina S
2, 3
,
Khrenov Maxim O
1
,
Glushkova Olga V
1
,
Prokhorov Dmitry
2, 3
,
Kutyshenko Viktor P
2, 3
,
Kovtun Anatoly L
4
3
4
Russian Foundation for Advanced Research, Russia.
|
Publication type: Journal Article
Publication date: 2019-02-01
Journal:
Life Sciences
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 6.1
ISSN: 00243205, 18790631
General Biochemistry, Genetics and Molecular Biology
General Medicine
General Pharmacology, Toxicology and Pharmaceutics
Abstract
To initiate a state of artificial torpor we suggested a pharmacological multi-targeting strategy for simulation of the physiological pattern of natural hibernation including a significant reduction in heart rate, respiratory rate, body temperature and oxygen consumption as well as a decline in brain activity known as torpor.We have developed a composition which initiates a pharmacologically induced torpor-like state (PITS-composition), made up of eight therapeutic agents, inert gas xenon and lipid emulsion served as a drug vehicle.After a single intravenous injection to rats, PITS-composition causes a rapid decline in heart rate followed by a steady decrease in body temperature from about 38.5 °C to 31.5 °C, at ambient temperature of 22 °C-23 °C. The hypothermic state may continue on average for 16-17 h with the subsequent spontaneous return of heart rate and body temperature to the initial values. In the open field test at torpor the motility, rearing and grooming were suppressed but 4-8 days later they were restored.Suspended animation states, including natural hibernation or pharmacologically induced synthetic torpor are of special attention of medicine, since it may improve survival rate after cardiac arrest, brain hemorrhage and ischemia, and during long-term space traveling. The suggested here multi-targeting strategy made possible to develop the pharmacological composition able, after a single intravenous injection, to initiate long, stable and reversible hypothermia and torpor at room temperature. After the torpor, animals were able to spontaneously restore both physiological parameters, and behavioral reactions.
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- We do not take into account publications that without a DOI.
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- Statistics recalculated weekly.
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Zakharova N. M. et al. A pharmacological composition for induction of a reversible torpor-like state and hypothermia in rats // Life Sciences. 2019. Vol. 219. pp. 190-198.
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Zakharova N. M., Tarahovsky Y. S., Fadeeva I. S., Komelina N. P., Khrenov M. O., Glushkova O. V., Prokhorov D., Kutyshenko V. P., Kovtun A. L. A pharmacological composition for induction of a reversible torpor-like state and hypothermia in rats // Life Sciences. 2019. Vol. 219. pp. 190-198.
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TY - JOUR
DO - 10.1016/j.lfs.2019.01.023
UR - https://doi.org/10.1016%2Fj.lfs.2019.01.023
TI - A pharmacological composition for induction of a reversible torpor-like state and hypothermia in rats
T2 - Life Sciences
AU - Zakharova, Nadezhda M
AU - Tarahovsky, Yury S
AU - Fadeeva, Irina S
AU - Komelina, Natalia P
AU - Khrenov, Maxim O
AU - Glushkova, Olga V
AU - Prokhorov, Dmitry
AU - Kutyshenko, Viktor P
AU - Kovtun, Anatoly L
PY - 2019
DA - 2019/02/01 00:00:00
PB - Elsevier
SP - 190-198
VL - 219
SN - 0024-3205
SN - 1879-0631
ER -
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@article{2019_Zakharova,
author = {Nadezhda M Zakharova and Yury S Tarahovsky and Irina S Fadeeva and Natalia P Komelina and Maxim O Khrenov and Olga V Glushkova and Dmitry Prokhorov and Viktor P Kutyshenko and Anatoly L Kovtun},
title = {A pharmacological composition for induction of a reversible torpor-like state and hypothermia in rats},
journal = {Life Sciences},
year = {2019},
volume = {219},
publisher = {Elsevier},
month = {feb},
url = {https://doi.org/10.1016%2Fj.lfs.2019.01.023},
pages = {190--198},
doi = {10.1016/j.lfs.2019.01.023}
}