Open Access
Open access
Elsevier
Life Sciences
,  volume 353 ,  pages 122931

The role of liquid-liquid phase separation in defining cancer EMT

Yuan Li 1
, 
Yuqing Feng 2
, 
SONGMEI GENG 3
, 
Feng Xu 4
, 
Hui Guo 5
1
 
2
 
3
 
4
 
5
 
Publication type: Journal Article
Publication date: 2024-09-01
Elsevier
scimago Q1
wos Q1
SJR: 1.315
CiteScore: 10.9
Impact factor: 5.1
ISSN: 00243205, 18790631
Abstract
Cancer EMT is a pivotal process that drives carcinogenesis, metastasis, and cancer recurrence, with its initiation and regulation intricately governed by biochemical pathways in a precise spatiotemporal manner. Recently, the membrane-less biomolecular condensates formed via liquid-liquid phase separation (LLPS) have emerged as a universal mechanism underlying the spatiotemporal collaboration of biological activities in cancer EMT. In this review, we first elucidate the current understanding of LLPS formation and its cellular functions, followed by an overview of valuable tools for investigating LLPS. Secondly, we examine in detail the LLPS-mediated biological processes crucial for the initiation and regulation of cancer EMT. Lastly, we address current challenges in advancing LLPS research and explore the potential modulation of LLPS using therapeutic agents.
Found 
Found 

Top-30

Journals

1
Cancer Letters
Cancer Letters, 1, 20%
Cancer Letters
1 publication, 20%
Advanced Science
Advanced Science, 1, 20%
Advanced Science
1 publication, 20%
Molecular and Cellular Biology
Molecular and Cellular Biology, 1, 20%
Molecular and Cellular Biology
1 publication, 20%
MedComm – Oncology
MedComm – Oncology, 1, 20%
MedComm – Oncology
1 publication, 20%
World Academy of Sciences Journal
World Academy of Sciences Journal, 1, 20%
World Academy of Sciences Journal
1 publication, 20%
1

Publishers

1
2
Wiley
Wiley, 2, 40%
Wiley
2 publications, 40%
Elsevier
Elsevier, 1, 20%
Elsevier
1 publication, 20%
Taylor & Francis
Taylor & Francis, 1, 20%
Taylor & Francis
1 publication, 20%
Spandidos Publications
Spandidos Publications, 1, 20%
Spandidos Publications
1 publication, 20%
1
2
  • We do not take into account publications without a DOI.
  • Statistics recalculated weekly.

Are you a researcher?

Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
5
Share
Cite this
GOST |
Cite this
GOST Copy
Li Y. et al. The role of liquid-liquid phase separation in defining cancer EMT // Life Sciences. 2024. Vol. 353. p. 122931.
GOST all authors (up to 50) Copy
Li Y., Feng Y., GENG S., Xu F., Guo H. The role of liquid-liquid phase separation in defining cancer EMT // Life Sciences. 2024. Vol. 353. p. 122931.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1016/j.lfs.2024.122931
UR - https://linkinghub.elsevier.com/retrieve/pii/S0024320524005216
TI - The role of liquid-liquid phase separation in defining cancer EMT
T2 - Life Sciences
AU - Li, Yuan
AU - Feng, Yuqing
AU - GENG, SONGMEI
AU - Xu, Feng
AU - Guo, Hui
PY - 2024
DA - 2024/09/01
PB - Elsevier
SP - 122931
VL - 353
PMID - 39038510
SN - 0024-3205
SN - 1879-0631
ER -
BibTex
Cite this
BibTex (up to 50 authors) Copy
@article{2024_Li,
author = {Yuan Li and Yuqing Feng and SONGMEI GENG and Feng Xu and Hui Guo},
title = {The role of liquid-liquid phase separation in defining cancer EMT},
journal = {Life Sciences},
year = {2024},
volume = {353},
publisher = {Elsevier},
month = {sep},
url = {https://linkinghub.elsevier.com/retrieve/pii/S0024320524005216},
pages = {122931},
doi = {10.1016/j.lfs.2024.122931}
}
Profiles