Life Sciences in Space Research, volume 28, pages 18-21
Long-term pharmacological torpor of rats with feedback-controlled drug administration
2
3
Russian Foundation for Advanced Research, Russia.
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Publication type: Journal Article
Publication date: 2021-02-01
Journal:
Life Sciences in Space Research
Quartile SCImago
Q2
Quartile WOS
Q3
Impact factor: 2.5
ISSN: 22145524, 22145532
Radiation
Health, Toxicology and Mutagenesis
Ecology
Astronomy and Astrophysics
Agricultural and Biological Sciences (miscellaneous)
Abstract
The maintenance of pharmacological torpor and hypothermia (body temperature 28 °C - 33 °C) in rats for a week is presented. For this purpose, our laboratory has developed a device (BioFeedback-2) for the feed-back controlled multiple injections of small doses of a pharmacological composition that we created earlier. On the 7th day, the rat spontaneously come out of the pharmacological torpor, the body temperature returned to normal, and on the 8th day, the animal could consume food and water. The proposed approach for maintaining multi-day pharmacological torpor can be applied in medicine, as well as for protecting astronauts during long missions in space.
Citations by journals
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1
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Journal of Pharmaceutical Sciences
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Journal of Pharmaceutical Sciences
1 publication, 33.33%
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Journal of Thermal Biology
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Journal of Thermal Biology
1 publication, 33.33%
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Nature Metabolism
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Nature Metabolism
1 publication, 33.33%
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1
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Citations by publishers
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1
2
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Elsevier
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Elsevier
2 publications, 66.67%
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Springer Nature
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Springer Nature
1 publication, 33.33%
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1
2
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- We do not take into account publications that without a DOI.
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Zakharova N. M. et al. Long-term pharmacological torpor of rats with feedback-controlled drug administration // Life Sciences in Space Research. 2021. Vol. 28. pp. 18-21.
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Zakharova N. M., Tarahovsky Y. S., Komelina N. P., Fadeeva I. S., Kovtun A. L. Long-term pharmacological torpor of rats with feedback-controlled drug administration // Life Sciences in Space Research. 2021. Vol. 28. pp. 18-21.
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TY - JOUR
DO - 10.1016/j.lssr.2020.11.002
UR - https://doi.org/10.1016%2Fj.lssr.2020.11.002
TI - Long-term pharmacological torpor of rats with feedback-controlled drug administration
T2 - Life Sciences in Space Research
AU - Zakharova, Nadezhda M
AU - Tarahovsky, Yury S.
AU - Komelina, Natalia P
AU - Fadeeva, Irina S.
AU - Kovtun, Anatoly L
PY - 2021
DA - 2021/02/01 00:00:00
PB - Elsevier
SP - 18-21
VL - 28
SN - 2214-5524
SN - 2214-5532
ER -
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@article{2021_Zakharova,
author = {Nadezhda M Zakharova and Yury S. Tarahovsky and Natalia P Komelina and Irina S. Fadeeva and Anatoly L Kovtun},
title = {Long-term pharmacological torpor of rats with feedback-controlled drug administration},
journal = {Life Sciences in Space Research},
year = {2021},
volume = {28},
publisher = {Elsevier},
month = {feb},
url = {https://doi.org/10.1016%2Fj.lssr.2020.11.002},
pages = {18--21},
doi = {10.1016/j.lssr.2020.11.002}
}