Mendeleev Communications
,  volume 30 ,  issue 5 ,  pages 630-632

Functionalization of 1,2-diphenylpyrazolidine-3,5-dione with polyfluoroalkyl-containing 2- and 3-oxo esters

Publication type: Journal Article
Publication date: 2020-09-01
scimago Q3
wos Q3
SJR: 0.305
CiteScore: 3.0
Impact factor: 1.7
ISSN: 09599436, 1364551X
General Chemistry
Abstract
Fluorine-containing analogues of non-steroidal antiinflammatory drugs Tribuzone and Ketazone have been synthesized by reaction of 1,2-diphenylpyrazolidine-3,5-dione with polyfluoroalkyl-containing 3- and 2-oxo esters. Ethyl 3-(pyrazolidin-4-yl)-3-(polyfluoroalkyl)prop-2-enoates have been obtained as Knoevenagel reaction products from 3-oxo esters in the presence of l-proline. Unlike with 3-oxo esters, addition of ethyl 3,3,3-trifluoro-2-oxopropanoate under basic conditions afforded ethyl 2-(pyrazolidin-4-yl)-3,3,3-trifluoro-2-hydroxypropanoate or its salt without elimination of a water molecule.
Found 
Found 
1 citation
Krasnykh Olga
PhD in Chemistry
49 publications,  505 citations
h-index: 11
Perm National Research Polytechnic University
Perm National Research Polytechnic University
Research interests
Drug design
Synthetic Organic Chemistry
1 citation
Malysheva K
9 publications,  27 citations
h-index: 3
Perm National Research Polytechnic University
Perm National Research Polytechnic University
1 citation
Triandafilova Galina
23 publications,  176 citations
h-index: 10
Perm National Research Polytechnic University
Perm National Research Polytechnic University
Institute of Ecology and Genetics of Microorganisms of the Ural Branch of the Russian Academy of Sciences
Institute of Ecology and Genetics of Microorganisms of the Ural Branch of the Russian Academy of Sciences
Research interests
Antioxidants
Microbiology
1 citation
Shchegolkov Evgeny
70 publications,  927 citations,  57 reviews
h-index: 16
Postovsky Institute of Organic Synthesis of the Ural Branch of the Russian Academy of Sciences
Postovsky Institute of Organic Synthesis of the Ural Branch of the Russian Academy of Sciences
Research interests
Organic synthesis

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Khudina O., Burgart Y. V., Saloutin V. Functionalization of 1,2-diphenylpyrazolidine-3,5-dione with polyfluoroalkyl-containing 2- and 3-oxo esters // Mendeleev Communications. 2020. Vol. 30. No. 5. pp. 630-632.
GOST all authors (up to 50) Copy
Khudina O., Burgart Y. V., Saloutin V. Functionalization of 1,2-diphenylpyrazolidine-3,5-dione with polyfluoroalkyl-containing 2- and 3-oxo esters // Mendeleev Communications. 2020. Vol. 30. No. 5. pp. 630-632.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1016/j.mencom.2020.09.026
UR - https://doi.org/10.1016/j.mencom.2020.09.026
TI - Functionalization of 1,2-diphenylpyrazolidine-3,5-dione with polyfluoroalkyl-containing 2- and 3-oxo esters
T2 - Mendeleev Communications
AU - Khudina, O.G.
AU - Burgart, Yanina V.
AU - Saloutin, Victor
PY - 2020
DA - 2020/09/01
PB - OOO Zhurnal "Mendeleevskie Soobshcheniya"
SP - 630-632
IS - 5
VL - 30
SN - 0959-9436
SN - 1364-551X
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2020_Khudina,
author = {O.G. Khudina and Yanina V. Burgart and Victor Saloutin},
title = {Functionalization of 1,2-diphenylpyrazolidine-3,5-dione with polyfluoroalkyl-containing 2- and 3-oxo esters},
journal = {Mendeleev Communications},
year = {2020},
volume = {30},
publisher = {OOO Zhurnal "Mendeleevskie Soobshcheniya"},
month = {sep},
url = {https://doi.org/10.1016/j.mencom.2020.09.026},
number = {5},
pages = {630--632},
doi = {10.1016/j.mencom.2020.09.026}
}
MLA
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Khudina, O.G., et al. “Functionalization of 1,2-diphenylpyrazolidine-3,5-dione with polyfluoroalkyl-containing 2- and 3-oxo esters.” Mendeleev Communications, vol. 30, no. 5, Sep. 2020, pp. 630-632. https://doi.org/10.1016/j.mencom.2020.09.026.