Mendeleev Communications
,  volume 33 ,  issue 2 ,  pages 194-196

Synthesis of new analgesics based on 4-isopropyl-1-phenyl-3-(trifluoromethyl)pyrazol-5-one

Publication type: Journal Article
Publication date: 2023-03-01
scimago Q3
wos Q3
SJR: 0.305
CiteScore: 3.0
Impact factor: 1.7
ISSN: 09599436, 1364551X
General Chemistry
Abstract
Methyl 4-trifluoro-2-isopropyl-4-oxobutanoate prepared by the improved procedure was cyclized with hydrazines to afford the title pyrazole derivatives. N- and O-alkylation of 4-isopropyl-1-phenyl-3-(trifluoromethyl)pyrazol-5-ol gave trifluoromethyl analogues of Propyphenazone and 5-alkoxy derivatives. 4-Isopropylpyrazoles containing O-butoxy moiety with a terminal trifluoromethyl or acyloxy group were found to demonstrate a promising analgesic activity.
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GOST Copy
Lapshin L. S. et al. Synthesis of new analgesics based on 4-isopropyl-1-phenyl-3-(trifluoromethyl)pyrazol-5-one // Mendeleev Communications. 2023. Vol. 33. No. 2. pp. 194-196.
GOST all authors (up to 50) Copy
Lapshin L. S., Shchegol’kov E., Burgart Y. V., Triandafilova G. A., Krasnykh O. P., Malysheva K. O., Saloutin V. I. Synthesis of new analgesics based on 4-isopropyl-1-phenyl-3-(trifluoromethyl)pyrazol-5-one // Mendeleev Communications. 2023. Vol. 33. No. 2. pp. 194-196.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1016/j.mencom.2023.02.014
UR - https://doi.org/10.1016/j.mencom.2023.02.014
TI - Synthesis of new analgesics based on 4-isopropyl-1-phenyl-3-(trifluoromethyl)pyrazol-5-one
T2 - Mendeleev Communications
AU - Lapshin, Luka S
AU - Shchegol’kov, E.V.
AU - Burgart, Yanina V.
AU - Triandafilova, Galina A
AU - Krasnykh, Olga P
AU - Malysheva, Kseniya O.
AU - Saloutin, Victor I.
PY - 2023
DA - 2023/03/01
PB - OOO Zhurnal "Mendeleevskie Soobshcheniya"
SP - 194-196
IS - 2
VL - 33
SN - 0959-9436
SN - 1364-551X
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2023_Lapshin,
author = {Luka S Lapshin and E.V. Shchegol’kov and Yanina V. Burgart and Galina A Triandafilova and Olga P Krasnykh and Kseniya O. Malysheva and Victor I. Saloutin},
title = {Synthesis of new analgesics based on 4-isopropyl-1-phenyl-3-(trifluoromethyl)pyrazol-5-one},
journal = {Mendeleev Communications},
year = {2023},
volume = {33},
publisher = {OOO Zhurnal "Mendeleevskie Soobshcheniya"},
month = {mar},
url = {https://doi.org/10.1016/j.mencom.2023.02.014},
number = {2},
pages = {194--196},
doi = {10.1016/j.mencom.2023.02.014}
}
MLA
Cite this
MLA Copy
Lapshin, Luka S., et al. “Synthesis of new analgesics based on 4-isopropyl-1-phenyl-3-(trifluoromethyl)pyrazol-5-one.” Mendeleev Communications, vol. 33, no. 2, Mar. 2023, pp. 194-196. https://doi.org/10.1016/j.mencom.2023.02.014.