Mendeleev Communications
,  volume 33 ,  issue 3 ,  pages 323-324

Spirocyclic azetidines for drug discovery: Novel Boc-protected 7'H-spiro[azetidine-3,5'-furo[3,4-d ]pyrimidines]

Publication type: Journal Article
Publication date: 2023-05-19
scimago Q3
wos Q3
SJR: 0.305
CiteScore: 3.0
Impact factor: 1.7
ISSN: 09599436, 1364551X
General Chemistry
Abstract
A novel spirocyclic scaffold of 7'H-spiro[azetidine-3,5'-furo[3,4-d]pyrimidine] chemotype was synthesized in N-Boc-protected form. However, the scaffold was revealed to be unstable to storage when deprotected. The solution was found in the brief removal of the Boc protecting group and rapid acylation of the liberated NH-azetidine with a carboxylic acid imidazolide.
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GOST Copy
Lukin A. Y. et al. Spirocyclic azetidines for drug discovery: Novel Boc-protected 7'H-spiro[azetidine-3,5'-furo[3,4-d ]pyrimidines] // Mendeleev Communications. 2023. Vol. 33. No. 3. pp. 323-324.
GOST all authors (up to 50) Copy
Lukin A. Y., Vinogradova L., Komarova K., Krasavin M. Spirocyclic azetidines for drug discovery: Novel Boc-protected 7'H-spiro[azetidine-3,5'-furo[3,4-d ]pyrimidines] // Mendeleev Communications. 2023. Vol. 33. No. 3. pp. 323-324.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1016/j.mencom.2023.04.008
UR - https://doi.org/10.1016/j.mencom.2023.04.008
TI - Spirocyclic azetidines for drug discovery: Novel Boc-protected 7'H-spiro[azetidine-3,5'-furo[3,4-d ]pyrimidines]
T2 - Mendeleev Communications
AU - Lukin, Alexey Yu.
AU - Vinogradova, Lyubov
AU - Komarova, Kristina
AU - Krasavin, Mikhail
PY - 2023
DA - 2023/05/19
PB - OOO Zhurnal "Mendeleevskie Soobshcheniya"
SP - 323-324
IS - 3
VL - 33
SN - 0959-9436
SN - 1364-551X
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2023_Lukin,
author = {Alexey Yu. Lukin and Lyubov Vinogradova and Kristina Komarova and Mikhail Krasavin},
title = {Spirocyclic azetidines for drug discovery: Novel Boc-protected 7'H-spiro[azetidine-3,5'-furo[3,4-d ]pyrimidines]},
journal = {Mendeleev Communications},
year = {2023},
volume = {33},
publisher = {OOO Zhurnal "Mendeleevskie Soobshcheniya"},
month = {may},
url = {https://doi.org/10.1016/j.mencom.2023.04.008},
number = {3},
pages = {323--324},
doi = {10.1016/j.mencom.2023.04.008}
}
MLA
Cite this
MLA Copy
Lukin, Alexey Yu., et al. “Spirocyclic azetidines for drug discovery: Novel Boc-protected 7'H-spiro[azetidine-3,5'-furo[3,4-d ]pyrimidines].” Mendeleev Communications, vol. 33, no. 3, May. 2023, pp. 323-324. https://doi.org/10.1016/j.mencom.2023.04.008.