Cetylpyridinium chloride is a potent AMP-activated kinase (AMPK) inducer and has therapeutic potential in cancer
Publication type: Journal Article
Publication date: 2020-01-01
scimago Q2
wos Q1
SJR: 1.242
CiteScore: 8.0
Impact factor: 4.5
ISSN: 15677249, 18728278
PubMed ID:
31654752
Molecular Biology
Cell Biology
Molecular Medicine
Abstract
AMP-activated protein kinase (AMPK) is a eukaryotic energy sensor and protector from mitochondrial/energetic stress that is also a therapeutic target for cancer and metabolic disease. Metformin is an AMPK inducer that has been used in cancer therapeutic trials. Through screening we isolated cetylpyridinium chloride (CPC), a drug known to dose-dependently inhibit mitochondrial complex 1, as a potent and dose-dependent AMPK stimulator. Mitochondrial biogenesis and bioenergetics changes have also been implicated in glioblastoma, which is the most aggressive form of brain tumors. Cetylpyridinium chloride has been administered in humans as a safe drug-disinfectant for several decades, and we report here that under in vitro conditions, cetylpyridinium chloride kills glioblastoma cells in a dose dependent manner at a higher efficacy compared to current standard of care drug, temozolomide.
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Allen S. A. et al. Cetylpyridinium chloride is a potent AMP-activated kinase (AMPK) inducer and has therapeutic potential in cancer // Mitochondrion. 2020. Vol. 50. pp. 19-24.
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Allen S. A., Datta S., Sandoval J., Tomilov A., Sears T., Woolard K. D., Angelastro J., Cortopassi G. Cetylpyridinium chloride is a potent AMP-activated kinase (AMPK) inducer and has therapeutic potential in cancer // Mitochondrion. 2020. Vol. 50. pp. 19-24.
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TY - JOUR
DO - 10.1016/j.mito.2019.09.009
UR - https://doi.org/10.1016/j.mito.2019.09.009
TI - Cetylpyridinium chloride is a potent AMP-activated kinase (AMPK) inducer and has therapeutic potential in cancer
T2 - Mitochondrion
AU - Allen, Sonia A
AU - Datta, Sandipan
AU - Sandoval, José
AU - Tomilov, Alexey
AU - Sears, Thomas
AU - Woolard, Kevin D.
AU - Angelastro, J.M.
AU - Cortopassi, Gino
PY - 2020
DA - 2020/01/01
PB - Elsevier
SP - 19-24
VL - 50
PMID - 31654752
SN - 1567-7249
SN - 1872-8278
ER -
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@article{2020_Allen,
author = {Sonia A Allen and Sandipan Datta and José Sandoval and Alexey Tomilov and Thomas Sears and Kevin D. Woolard and J.M. Angelastro and Gino Cortopassi},
title = {Cetylpyridinium chloride is a potent AMP-activated kinase (AMPK) inducer and has therapeutic potential in cancer},
journal = {Mitochondrion},
year = {2020},
volume = {50},
publisher = {Elsevier},
month = {jan},
url = {https://doi.org/10.1016/j.mito.2019.09.009},
pages = {19--24},
doi = {10.1016/j.mito.2019.09.009}
}