Mitochondrion, volume 72, pages 11-21
Type 1 Diabetes Mellitus: Inflammation, Mitophagy, and Mitochondrial Function
Blagov Alexander V
1
,
Summerhill Volha I.
2
,
Sukhorukov Vasily N.
1, 2
,
Popov M А
3
,
Grechko Andrey V.
4
,
Orekhov Alexander N.
1, 2
1
Publication type: Journal Article
Publication date: 2023-09-01
Journal:
Mitochondrion
Quartile SCImago
Q2
Quartile WOS
Q1
Impact factor: 4.4
ISSN: 15677249, 18728278
Molecular Biology
Cell Biology
Molecular Medicine
Abstract
Type 1 diabetes mellitus (T1DM) is a T-cell-mediated autoimmune disease characterized by the damage of insulin-secreting β-cells in the pancreatic islets of Langerhans. To date, its etiology is not fully understood, despite decades of active search for root causes, and that underlines the complexity of the disease pathogenesis. It was found that mitophagy plays a regulatory role in the development of autoimmune response during T1DM pathogenesis by preventing the accumulation of defective/dysfunctional mitochondria in pancreatic cells. Mitochondrial dysfunction due to impaired mitophagy with the release of mitochondrial reactive oxygen species (mtROS) and mitochondrial DNA (mtDNA) contributes to initiating an inflammatory response by elevating pro-inflammatory cytokines and interacting with receptors like those involved in the pathogen-associated response. Moreover, mtROS and mtDNA activate pathways leading to the development of chronic inflammation, which is tightly implicated in T1DM autoimmunity. In this review, we summarized the evidence highlighting the functional role of mitophagy and mitochondria in the development of immune response and chronic inflammation during T1DM pathogenesis. Several anti-inflammatory and mitophagy-related treatment options have been explored.
Citations by journals
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International Journal of Immunopathology and Pharmacology
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International Journal of Immunopathology and Pharmacology
1 publication, 50%
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Frontiers in Molecular Biosciences
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Frontiers in Molecular Biosciences
1 publication, 50%
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1
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Citations by publishers
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1
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SAGE
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SAGE
1 publication, 50%
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Frontiers Media S.A.
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Frontiers Media S.A.
1 publication, 50%
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1
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Blagov A. V. et al. Type 1 Diabetes Mellitus: Inflammation, Mitophagy, and Mitochondrial Function // Mitochondrion. 2023. Vol. 72. pp. 11-21.
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Blagov A. V., Summerhill V. I., Sukhorukov V. N., Popov M. А., Grechko A. V., Orekhov A. N. Type 1 Diabetes Mellitus: Inflammation, Mitophagy, and Mitochondrial Function // Mitochondrion. 2023. Vol. 72. pp. 11-21.
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TY - JOUR
DO - 10.1016/j.mito.2023.07.002
UR - https://doi.org/10.1016%2Fj.mito.2023.07.002
TI - Type 1 Diabetes Mellitus: Inflammation, Mitophagy, and Mitochondrial Function
T2 - Mitochondrion
AU - Blagov, Alexander V
AU - Summerhill, Volha I.
AU - Sukhorukov, Vasily N.
AU - Popov, M А
AU - Grechko, Andrey V.
AU - Orekhov, Alexander N.
PY - 2023
DA - 2023/09/01 00:00:00
PB - Elsevier
SP - 11-21
VL - 72
SN - 1567-7249
SN - 1872-8278
ER -
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@article{2023_Blagov,
author = {Alexander V Blagov and Volha I. Summerhill and Vasily N. Sukhorukov and M А Popov and Andrey V. Grechko and Alexander N. Orekhov},
title = {Type 1 Diabetes Mellitus: Inflammation, Mitophagy, and Mitochondrial Function},
journal = {Mitochondrion},
year = {2023},
volume = {72},
publisher = {Elsevier},
month = {sep},
url = {https://doi.org/10.1016%2Fj.mito.2023.07.002},
pages = {11--21},
doi = {10.1016/j.mito.2023.07.002}
}