Molecular Cell

, volume 69 , issue 5 , pages 840-85200000

Unique Structural Platforms of Suz12 Dictate Distinct Classes of PRC2 for Chromatin Binding

Siming Chen ¹

Lianying Jiao ¹

Murtada Shubbar ¹

Xin Yang ¹

Xin Liu ¹

Hide authors affiliations Show authors affiliations: 1 affiliation

Cecil H. and Ida Green Center for Reproductive Biology Sciences and Division of Basic Research, Department of Obstetrics and Gynecology, Department of Biophysics, UT Southwestern Medical Center, Dallas, TX 75390, USA. |

Publication type: Journal Article

Publication date: 2018-03-01

Elsevier

Molecular Cell

scimago Q1

wos Q1

SJR: 9.051

CiteScore: 24.4

Impact factor: 16.6

ISSN: 10972765, 10974164

DOI: 10.1016/j.molcel.2018.01.039

Copy DOI

PubMed ID: 29499137

Molecular Biology

Cell Biology

Abstract

Summary Developmentally regulated accessory subunits dictate PRC2 function. Here, we report the crystal structures of a 120 kDa heterotetrameric complex consisting of Suz12, Rbbp4, Jarid2, and Aebp2 fragments that is minimally active in nucleosome binding and of an inactive binary complex of Suz12 and Rbbp4. Suz12 contains two unique structural platforms that define distinct classes of PRC2 holo complexes for chromatin binding. Aebp2 and Phf19 compete for binding of a non-canonical C2 domain of Suz12; Jarid2 and EPOP occupy an overlapped Suz12 surface required for chromatin association of PRC2. Suz12 and Aebp2 progressively block histone H3K4 binding to Rbbp4, suggesting that Rbbp4 may not be directly involved in PRC2 inhibition by the active H3K4me3 histone mark. Nucleosome binding enabled by Jarid2 and Aebp2 is in part accounted for by the structures, which also reveal that disruption of the Jarid2-Suz12 interaction may underlie the disease mechanism of an oncogenic chromosomal translocation of Suz12.

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GOST |

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GOST Copy

Chen S. et al. Unique Structural Platforms of Suz12 Dictate Distinct Classes of PRC2 for Chromatin Binding // Molecular Cell. 2018. Vol. 69. No. 5. pp. 840-85200000.

GOST all authors (up to 50) Copy

Chen S., Jiao L., Shubbar M., Yang X., Liu X. Unique Structural Platforms of Suz12 Dictate Distinct Classes of PRC2 for Chromatin Binding // Molecular Cell. 2018. Vol. 69. No. 5. pp. 840-85200000.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1016/j.molcel.2018.01.039

UR - https://doi.org/10.1016/j.molcel.2018.01.039

TI - Unique Structural Platforms of Suz12 Dictate Distinct Classes of PRC2 for Chromatin Binding

T2 - Molecular Cell

AU - Chen, Siming

AU - Jiao, Lianying

AU - Shubbar, Murtada

AU - Yang, Xin

AU - Liu, Xin

PY - 2018

DA - 2018/03/01

PB - Elsevier

SP - 840-85200000

IS - 5

VL - 69

PMID - 29499137

SN - 1097-2765

SN - 1097-4164

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2018_Chen,

author = {Siming Chen and Lianying Jiao and Murtada Shubbar and Xin Yang and Xin Liu},

title = {Unique Structural Platforms of Suz12 Dictate Distinct Classes of PRC2 for Chromatin Binding},

journal = {Molecular Cell},

year = {2018},

volume = {69},

publisher = {Elsevier},

month = {mar},

url = {https://doi.org/10.1016/j.molcel.2018.01.039},

number = {5},

pages = {840--85200000},

doi = {10.1016/j.molcel.2018.01.039}

}

MLA

Cite this

MLA Copy

Chen, Siming, et al. “Unique Structural Platforms of Suz12 Dictate Distinct Classes of PRC2 for Chromatin Binding.” Molecular Cell, vol. 69, no. 5, Mar. 2018, pp. 840-85200000. https://doi.org/10.1016/j.molcel.2018.01.039.

Publisher

Elsevier

Journal

Molecular Cell

scimago Q1

wos Q1

SJR

9.051

CiteScore

24.4

Impact factor

16.6

ISSN

10972765 (Print)

10974164 (Electronic)