A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities
Eric Conway
,
Emilia Jerman
,
Evan Healy
,
Shinsuke Ito
,
Daniel Holoch
,
Giorgio Oliviero
,
Orla Deevy
,
Eleanor Glancy
,
Darren J Fitzpatrick
,
Marlena Mucha
,
Ariane Watson
,
Alan M. Rice
,
Paul Chammas
,
Christine Huang
,
Indigo Pratt Kelly
,
Yoko Koseki
,
Manabu Nakayama
,
Tomoyuki ISHIKURA
,
Gundula Streubel
,
Kieran Wynne
,
Karsten Hokamp
,
Aoife Mclysaght
,
Claudio Ciferri
,
Luciano Di Croce
,
Gerard Cagney
,
Raphael Margueron
,
Haruhiko Koseki
,
Adrian P Bracken
Publication type: Journal Article
Publication date: 2018-05-01
scimago Q1
wos Q1
SJR: 9.051
CiteScore: 24.4
Impact factor: 16.6
ISSN: 10972765, 10974164
PubMed ID:
29628311
Molecular Biology
Cell Biology
Abstract
The polycomb repressive complex 2 (PRC2) consists of core subunits SUZ12, EED, RBBP4/7, and EZH1/2 and is responsible for mono-, di-, and tri-methylation of lysine 27 on histone H3. Whereas two distinct forms exist, PRC2.1 (containing one polycomb-like protein) and PRC2.2 (containing AEBP2 and JARID2), little is known about their differential functions. Here, we report the discovery of a family of vertebrate-specific PRC2.1 proteins, "PRC2 associated LCOR isoform 1" (PALI1) and PALI2, encoded by the LCOR and LCORL gene loci, respectively. PALI1 promotes PRC2 methyltransferase activity in vitro and in vivo and is essential for mouse development. Pali1 and Aebp2 define mutually exclusive, antagonistic PRC2 subtypes that exhibit divergent H3K27-tri-methylation activities. The balance of these PRC2.1/PRC2.2 activities is required for the appropriate regulation of polycomb target genes during differentiation. PALI1/2 potentially link polycombs with transcriptional co-repressors in the regulation of cellular identity during development and in cancer.
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GOST
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Conway E. et al. A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities // Molecular Cell. 2018. Vol. 70. No. 3. p. 408-421.e8.
GOST all authors (up to 50)
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Conway E., Jerman E., Healy E., Ito S., Holoch D., Oliviero G., Deevy O., Glancy E., Fitzpatrick D. J., Mucha M., Watson A., Rice A. M., Chammas P., Huang C., Pratt Kelly I., Koseki Y., Nakayama M., ISHIKURA T., Streubel G., Wynne K., Hokamp K., Mclysaght A., Ciferri C., Di Croce L., Cagney G., Margueron R., Koseki H., Bracken A. P. A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities // Molecular Cell. 2018. Vol. 70. No. 3. p. 408-421.e8.
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RIS
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TY - JOUR
DO - 10.1016/j.molcel.2018.03.005
UR - https://doi.org/10.1016/j.molcel.2018.03.005
TI - A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities
T2 - Molecular Cell
AU - Conway, Eric
AU - Jerman, Emilia
AU - Healy, Evan
AU - Ito, Shinsuke
AU - Holoch, Daniel
AU - Oliviero, Giorgio
AU - Deevy, Orla
AU - Glancy, Eleanor
AU - Fitzpatrick, Darren J
AU - Mucha, Marlena
AU - Watson, Ariane
AU - Rice, Alan M.
AU - Chammas, Paul
AU - Huang, Christine
AU - Pratt Kelly, Indigo
AU - Koseki, Yoko
AU - Nakayama, Manabu
AU - ISHIKURA, Tomoyuki
AU - Streubel, Gundula
AU - Wynne, Kieran
AU - Hokamp, Karsten
AU - Mclysaght, Aoife
AU - Ciferri, Claudio
AU - Di Croce, Luciano
AU - Cagney, Gerard
AU - Margueron, Raphael
AU - Koseki, Haruhiko
AU - Bracken, Adrian P
PY - 2018
DA - 2018/05/01
PB - Elsevier
SP - 408-421.e8
IS - 3
VL - 70
PMID - 29628311
SN - 1097-2765
SN - 1097-4164
ER -
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@article{2018_Conway,
author = {Eric Conway and Emilia Jerman and Evan Healy and Shinsuke Ito and Daniel Holoch and Giorgio Oliviero and Orla Deevy and Eleanor Glancy and Darren J Fitzpatrick and Marlena Mucha and Ariane Watson and Alan M. Rice and Paul Chammas and Christine Huang and Indigo Pratt Kelly and Yoko Koseki and Manabu Nakayama and Tomoyuki ISHIKURA and Gundula Streubel and Kieran Wynne and Karsten Hokamp and Aoife Mclysaght and Claudio Ciferri and Luciano Di Croce and Gerard Cagney and Raphael Margueron and Haruhiko Koseki and Adrian P Bracken},
title = {A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities},
journal = {Molecular Cell},
year = {2018},
volume = {70},
publisher = {Elsevier},
month = {may},
url = {https://doi.org/10.1016/j.molcel.2018.03.005},
number = {3},
pages = {408--421.e8},
doi = {10.1016/j.molcel.2018.03.005}
}
Cite this
MLA
Copy
Conway, Eric, et al. “A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities.” Molecular Cell, vol. 70, no. 3, May. 2018, pp. 408-421.e8. https://doi.org/10.1016/j.molcel.2018.03.005.