Open Access
Journal of Molecular Liquids, volume 345, pages 117031
Water-Soluble BODIPY-Based fluorescent probe for BSA and HSA detection
Publication type: Journal Article
Publication date: 2022-01-01
Journal:
Journal of Molecular Liquids
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 6
ISSN: 01677322, 18733166
Materials Chemistry
Electronic, Optical and Magnetic Materials
Physical and Theoretical Chemistry
Spectroscopy
Atomic and Molecular Physics, and Optics
Condensed Matter Physics
Abstract
• We have developed new BP1 fluorescent probe for selective detection of HSA in urine. • BP1 – SA complexes are formed predominantly due to the specific interactions. • BP1 – SA complex formation is accompanied by a strong BP1 fluorescence quenching. • BP1 fluorescence quenching is realized through FRET. Interaction of 4,4-difluoro-1,3,7,8-tetramethyl-2,6-disulfo-4-bora-3a,4a-diaza- s -indacene sodium salt (BODIPY, BP1 ) with bovine serum albumin (BSA) and human serum albumin (HSA) was investigated using spectral methods and molecular docking. It was shown that BP1 forms stable supramolecular complexes with BSA and HSA predominantly due to the specific interactions. Supramolecular complex formation was accompanied by strong fluorescence quenching of BP1 as a result of FRET. This effect could be used for the qualitative and quantitative detection of HSA in model physiological fluids. The detection limit of BSA and HSA were 0.26 and 0.05 mg·mL −1 , respectively. The selectivity of BP1 fluorescence response to the co-presence of BSA and HSA in solution was demonstrated. The BP1 fluorescent probe was successfully used for the qualitative and quantitative detection of HSA in human urine samples. The obtained results indicated the capability of using BP1 -based fluorescent sensors in clinical medicine for early detection of microalbuminuria and concomitant diseases.
Citations by journals
1
2
|
|
Dyes and Pigments
|
Dyes and Pigments
2 publications, 11.11%
|
Russian Journal of Inorganic Chemistry
|
Russian Journal of Inorganic Chemistry
1 publication, 5.56%
|
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
|
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
1 publication, 5.56%
|
Coordination Chemistry Reviews
|
Coordination Chemistry Reviews
1 publication, 5.56%
|
Journal of Molecular Liquids
|
Journal of Molecular Liquids
1 publication, 5.56%
|
Physical Chemistry Chemical Physics
|
Physical Chemistry Chemical Physics
1 publication, 5.56%
|
Frontiers in Bioengineering and Biotechnology
|
Frontiers in Bioengineering and Biotechnology
1 publication, 5.56%
|
Chemical Engineering Journal
|
Chemical Engineering Journal
1 publication, 5.56%
|
Journal of Applied Electrochemistry
|
Journal of Applied Electrochemistry
1 publication, 5.56%
|
ACS Omega
|
ACS Omega
1 publication, 5.56%
|
Organic and Biomolecular Chemistry
|
Organic and Biomolecular Chemistry
1 publication, 5.56%
|
Journal of Photochemistry and Photobiology A: Chemistry
|
Journal of Photochemistry and Photobiology A: Chemistry
1 publication, 5.56%
|
The Analyst
|
The Analyst
1 publication, 5.56%
|
Journal of Physical Chemistry B
|
Journal of Physical Chemistry B
1 publication, 5.56%
|
Journal of Molecular Structure
|
Journal of Molecular Structure
1 publication, 5.56%
|
International Journal of Biological Macromolecules
|
International Journal of Biological Macromolecules
1 publication, 5.56%
|
Langmuir
|
Langmuir
1 publication, 5.56%
|
1
2
|
Citations by publishers
1
2
3
4
5
6
7
8
9
|
|
Elsevier
|
Elsevier
9 publications, 50%
|
Royal Society of Chemistry (RSC)
|
Royal Society of Chemistry (RSC)
3 publications, 16.67%
|
American Chemical Society (ACS)
|
American Chemical Society (ACS)
3 publications, 16.67%
|
Pleiades Publishing
|
Pleiades Publishing
1 publication, 5.56%
|
Frontiers Media S.A.
|
Frontiers Media S.A.
1 publication, 5.56%
|
Springer Nature
|
Springer Nature
1 publication, 5.56%
|
1
2
3
4
5
6
7
8
9
|
- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[2022,2023,2024],"ids":[0,0,0],"codes":[0,0,0],"imageUrls":["","",""],"datasets":[{"label":"Citations number","data":[4,9,5],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6"],"percentage":["22.22","50","27.78"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["Dyes and Pigments","Russian Journal of Inorganic Chemistry","Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy","Coordination Chemistry Reviews","Journal of Molecular Liquids","Physical Chemistry Chemical Physics","Frontiers in Bioengineering and Biotechnology","Chemical Engineering Journal","Journal of Applied Electrochemistry","ACS Omega","Organic and Biomolecular Chemistry","Journal of Photochemistry and Photobiology A: Chemistry","The Analyst","Journal of Physical Chemistry B","Journal of Molecular Structure","International Journal of Biological Macromolecules","Langmuir"],"ids":[10101,426,6337,13437,13597,1773,13389,16275,12525,18901,541,18164,9343,14990,9347,23035,19601],"codes":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/oZgeErrVFhuDksyqFURLvYS1wtVSBWczh001igGo_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/leiAYcRDGTSl5B1eCnwpSGqmDEUEfDPPoYisFGhT_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/leiAYcRDGTSl5B1eCnwpSGqmDEUEfDPPoYisFGhT_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/leiAYcRDGTSl5B1eCnwpSGqmDEUEfDPPoYisFGhT_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp"],"datasets":[{"label":"","data":[2,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[11.11,5.56,5.56,5.56,5.56,5.56,5.56,5.56,5.56,5.56,5.56,5.56,5.56,5.56,5.56,5.56,5.56],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["Elsevier","Royal Society of Chemistry (RSC)","American Chemical Society (ACS)","Pleiades Publishing","Frontiers Media S.A.","Springer Nature"],"ids":[17,123,40,101,208,8],"codes":[0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/leiAYcRDGTSl5B1eCnwpSGqmDEUEfDPPoYisFGhT_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/oZgeErrVFhuDksyqFURLvYS1wtVSBWczh001igGo_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp"],"datasets":[{"label":"","data":[9,3,3,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[50,16.67,16.67,5.56,5.56,5.56],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}}}
Metrics
Cite this
GOST |
RIS |
BibTex
Cite this
GOST
Copy
Ksenofontov A. A. et al. Water-Soluble BODIPY-Based fluorescent probe for BSA and HSA detection // Journal of Molecular Liquids. 2022. Vol. 345. p. 117031.
GOST all authors (up to 50)
Copy
Ksenofontov A. A., Bocharov P. S., Ksenofontova K. V., Antina E. V. Water-Soluble BODIPY-Based fluorescent probe for BSA and HSA detection // Journal of Molecular Liquids. 2022. Vol. 345. p. 117031.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.molliq.2021.117031
UR - https://doi.org/10.1016%2Fj.molliq.2021.117031
TI - Water-Soluble BODIPY-Based fluorescent probe for BSA and HSA detection
T2 - Journal of Molecular Liquids
AU - Ksenofontov, Alexander A
AU - Bocharov, Pavel S
AU - Ksenofontova, Ksenia V
AU - Antina, Elena V
PY - 2022
DA - 2022/01/01 00:00:00
PB - Elsevier
SP - 117031
VL - 345
SN - 0167-7322
SN - 1873-3166
ER -
Cite this
BibTex
Copy
@article{2022_Ksenofontov,
author = {Alexander A Ksenofontov and Pavel S Bocharov and Ksenia V Ksenofontova and Elena V Antina},
title = {Water-Soluble BODIPY-Based fluorescent probe for BSA and HSA detection},
journal = {Journal of Molecular Liquids},
year = {2022},
volume = {345},
publisher = {Elsevier},
month = {jan},
url = {https://doi.org/10.1016%2Fj.molliq.2021.117031},
pages = {117031},
doi = {10.1016/j.molliq.2021.117031}
}