Low protein adsorption and high cellular activity of PEG-based silicone polyurethane for artificial heart valves
Sailong Wei
1, 2
,
Jiangjie Wu
1, 2
,
Gu Xiaokai
1, 2
,
Sufen Shen
1, 2
,
S. S. Shen
1, 2
,
Meng Ma
1, 2
,
Yanqin Shi
1, 2
,
He Huiwen
1, 2
,
Yulu Zhu
1, 2
,
Libo Shen
1, 2
,
Si Chen
1, 2
,
Xu Wang
1, 2
Publication type: Journal Article
Publication date: 2024-06-01
scimago Q1
wos Q2
SJR: 0.788
CiteScore: 5.8
Impact factor: 4.5
ISSN: 23524928
Abstract
Polyurethane have the advantages of convenient structural design, low production cost, and excellent mechanical compatibility, and is expected to be used as a polymer heart valve material. However, its development in biomaterials is limited because it is prone to hydrolysis and coagulation after long-term implantation in organisms. In this study, "PEG-MDI-PEG" macromolecular diol was prepared by structural design of the soft segment of polyurethane. Copolymerization with telechelic α,ω-bis(6-hydroxyethoxypropyl)-PDMS as mixed soft segment, prepolymer solution was prepared by solution polymerization, and the biocompatibility of silicone-based polyurethane obtained by casting was characterized. By adjusting the feed ratio to control the silicon content in the copolymer, when the silicon content was 60%, the protein adsorption capacity was 75% lower than that of unmodified polyurethane, and the cell activity was more than 80%, which was a useful characteristic for silicon-based polyurethane as a potential polymer valve material.
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Citations from 2024:
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(100%)
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GOST
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Wei S. et al. Low protein adsorption and high cellular activity of PEG-based silicone polyurethane for artificial heart valves // Materials Today Communications. 2024. Vol. 39. p. 109357.
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Wei S., Wu J., Xiaokai G., Shen S., Shen S. S., Ma M., Shi Y., He Huiwen, Zhu Y., Shen L., Chen S., Wang X. Low protein adsorption and high cellular activity of PEG-based silicone polyurethane for artificial heart valves // Materials Today Communications. 2024. Vol. 39. p. 109357.
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RIS
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TY - JOUR
DO - 10.1016/j.mtcomm.2024.109357
UR - https://linkinghub.elsevier.com/retrieve/pii/S2352492824013382
TI - Low protein adsorption and high cellular activity of PEG-based silicone polyurethane for artificial heart valves
T2 - Materials Today Communications
AU - Wei, Sailong
AU - Wu, Jiangjie
AU - Xiaokai, Gu
AU - Shen, Sufen
AU - Shen, S. S.
AU - Ma, Meng
AU - Shi, Yanqin
AU - He Huiwen
AU - Zhu, Yulu
AU - Shen, Libo
AU - Chen, Si
AU - Wang, Xu
PY - 2024
DA - 2024/06/01
PB - Elsevier
SP - 109357
VL - 39
SN - 2352-4928
ER -
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BibTex (up to 50 authors)
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@article{2024_Wei,
author = {Sailong Wei and Jiangjie Wu and Gu Xiaokai and Sufen Shen and S. S. Shen and Meng Ma and Yanqin Shi and He Huiwen and Yulu Zhu and Libo Shen and Si Chen and Xu Wang},
title = {Low protein adsorption and high cellular activity of PEG-based silicone polyurethane for artificial heart valves},
journal = {Materials Today Communications},
year = {2024},
volume = {39},
publisher = {Elsevier},
month = {jun},
url = {https://linkinghub.elsevier.com/retrieve/pii/S2352492824013382},
pages = {109357},
doi = {10.1016/j.mtcomm.2024.109357}
}