Open Access
Molecular Therapy - Nucleic Acids, volume 26, pages 1159-1172
11C-radiolabeled aptamer for imaging of tumors and metastases using positron emission tomography- computed tomography
Shchugoreva Irina A.
2
,
Zamay Galina S
,
Kolovskaya Olga S
,
Zabluda Vladimir N
3
,
Veprintsev Dmitry V
,
Tomilin Felix N.
3
,
Sil’nikov Vladimir N
,
Shepelevich Nikolay
1
,
Zamay Tatiana N.
,
Zamay Sergey S
,
Moryachkov R V
2
,
Belugin Kirill V
,
Chanchikova Natalia G
,
Badmaev Oleg N
1
,
Khorzhevskii Vladimir A
,
Gappoev Stanislav V
,
Karlova Elena A
1
,
Saveleva Anastasia S
1
,
Volzhentsev Alexander A
1
,
Blagodatova Anna N
5
,
Smolyarova Tatyana E
2
,
Zamay Tatiana N.
5
,
Kolovskaya Olga S.
5
,
Belugin Kirill
1
,
Chanchikova Natalia
1
,
Zamay Galina S.
5
,
Khorzhevskii Vladimir A
5
,
Gappoev Stanislav V
5
,
Veprintsev Dmitry B.
2
,
Zamay Sergey S.
2
,
SILNIKOV VLADIMIR
6
,
4
Department of Chemistry & Biomolecular Sciences, University of Ottawa,Ottawa,Canada
|
5
Publication type: Journal Article
Publication date: 2021-12-01
Journal:
Molecular Therapy - Nucleic Acids
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 8.8
ISSN: 21622531
PubMed ID:
34853715
Drug Discovery
Molecular Medicine
Abstract
Identification of primary tumors and metastasis sites is an essential step in cancer diagnostics and the following treatment. Positron emission tomography-computed tomography (PET/CT) is one of the most reliable methods for scanning the whole organism for malignancies. In this work, we synthesized an 11C-labeled oligonucleotide primer and hybridized it to an anti-cancer DNA aptamer. The 11C-aptamer was applied for in vivo imaging of Ehrlich ascites carcinoma and its metastases in mice using PET/CT. The imaging experiments with the 11C-aptamer determined very small primary and secondary tumors of 3 mm2 and less. We also compared 11C imaging with the standard radiotracer, 2-deoxy-2-[fluorine-18]fluoro-D-glucose (18F-FDG), and found better selectivity of the 11C-aptamer to metastatic lesions in the metabolically active organs than 18F-FDG. 11C radionuclide with an ultra-short (20.38 min) half-life is considered safest for PET/CT imaging and does not cause false-positive results in heart imaging. Its combination with aptamers gives us high-specificity and high-contrast imaging of cancer cells and can be applied for PET/CT-guided drug delivery in cancer therapies.
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Ozerskaya A. V. et al. 11C-radiolabeled aptamer for imaging of tumors and metastases using positron emission tomography- computed tomography // Molecular Therapy - Nucleic Acids. 2021. Vol. 26. pp. 1159-1172.
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Zamay T. N., Kichkailo A. S., Berezovski M. V., Sil’nikov V. N., Zamay S. S., Tomilin F. N., Smolyarova T. E., Veprintsev D. V., Lukyanenko K. A., Blagodatova A. N., Volzhentsev A. A., Saveleva A. S., Karlova E. A., Shepelevich N., Ozerskaya A. V., Kolovskaya O. S., Tokarev N. A., Belugin K. V., Chanchikova N. G., Badmaev O. N., Shchugoreva I. A., Moryachkov R. V., Zabluda V. N., Khorzhevskii V. A., Gappoev S. V., Zamay G. S., Zamay T. N., Kolovskaya O. S., Belugin K., Chanchikova N., Zamay G. S., Khorzhevskii V. A., Gappoev S. V., Veprintsev D. B., Zamay S. S., SILNIKOV V., Kichkailo A. S. 11C-radiolabeled aptamer for imaging of tumors and metastases using positron emission tomography- computed tomography // Molecular Therapy - Nucleic Acids. 2021. Vol. 26. pp. 1159-1172.
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TY - JOUR
DO - 10.1016/j.omtn.2021.10.020
UR - https://doi.org/10.1016%2Fj.omtn.2021.10.020
TI - 11C-radiolabeled aptamer for imaging of tumors and metastases using positron emission tomography- computed tomography
T2 - Molecular Therapy - Nucleic Acids
AU - Ozerskaya, Anastasia V
AU - Zamay, Tatiana N.
AU - Kolovskaya, Olga S
AU - Tokarev, Nikolay A
AU - Belugin, Kirill V
AU - Chanchikova, Natalia G
AU - Badmaev, Oleg N
AU - Zamay, Galina S
AU - Shchugoreva, Irina A.
AU - Moryachkov, R V
AU - Zabluda, Vladimir N
AU - Khorzhevskii, Vladimir A
AU - Shepelevich, Nikolay
AU - Gappoev, Stanislav V
AU - Karlova, Elena A
AU - Saveleva, Anastasia S
AU - Volzhentsev, Alexander A
AU - Blagodatova, Anna N
AU - Lukyanenko, Kirill A.
AU - Veprintsev, Dmitry V
AU - Smolyarova, Tatyana E
AU - Tomilin, Felix N.
AU - Zamay, Sergey S
AU - Sil’nikov, Vladimir N
AU - Berezovski, Maxim V.
AU - Kichkailo, Anna S.
AU - Zamay, Tatiana N.
AU - Kolovskaya, Olga S.
AU - Belugin, Kirill
AU - Chanchikova, Natalia
AU - Zamay, Galina S.
AU - Khorzhevskii, Vladimir A
AU - Gappoev, Stanislav V
AU - Veprintsev, Dmitry B.
AU - Zamay, Sergey S.
AU - SILNIKOV, VLADIMIR
AU - Kichkailo, Anna S
PY - 2021
DA - 2021/12/01 00:00:00
PB - Elsevier
SP - 1159-1172
VL - 26
PMID - 34853715
SN - 2162-2531
ER -
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@article{2021_Ozerskaya,
author = {Anastasia V Ozerskaya and Tatiana N. Zamay and Olga S Kolovskaya and Nikolay A Tokarev and Kirill V Belugin and Natalia G Chanchikova and Oleg N Badmaev and Galina S Zamay and Irina A. Shchugoreva and R V Moryachkov and Vladimir N Zabluda and Vladimir A Khorzhevskii and Nikolay Shepelevich and Stanislav V Gappoev and Elena A Karlova and Anastasia S Saveleva and Alexander A Volzhentsev and Anna N Blagodatova and Kirill A. Lukyanenko and Dmitry V Veprintsev and Tatyana E Smolyarova and Felix N. Tomilin and Sergey S Zamay and Vladimir N Sil’nikov and Maxim V. Berezovski and Anna S. Kichkailo and Tatiana N. Zamay and Olga S. Kolovskaya and Kirill Belugin and Natalia Chanchikova and Galina S. Zamay and Vladimir A Khorzhevskii and Stanislav V Gappoev and Dmitry B. Veprintsev and Sergey S. Zamay and VLADIMIR SILNIKOV and Anna S Kichkailo},
title = {11C-radiolabeled aptamer for imaging of tumors and metastases using positron emission tomography- computed tomography},
journal = {Molecular Therapy - Nucleic Acids},
year = {2021},
volume = {26},
publisher = {Elsevier},
month = {dec},
url = {https://doi.org/10.1016%2Fj.omtn.2021.10.020},
pages = {1159--1172},
doi = {10.1016/j.omtn.2021.10.020}
}